Ketamine Not Associated With PTSD Development in Military Trauma Setting

HealthDay News — Ketamine administration is not associated with post-traumatic stress disorder (PTSD) in the military trauma setting, according to a study published online in Anaesthesia.

Georges Mion, MD, from Cochin Hospital in France, and colleagues conducted a retrospective study using data from the French Military Health Service for 274 soldiers who survived a war injury in Afghanistan (2010-2012) to examine the correlation between ketamine and PTSD.

The researchers found that 36% of the soldiers suffered from PTSD and 32% had received ketamine. Fifty-five and 20% of patients in the PTSD group and the no-PTSD group, respectively, had received ketamine. 

The median injury severity score was 5 for injured soldiers who received ketamine compared with 3 among the soldiers who did not receive ketamine. Only acute stress disorder and total number of surgical procedures were correlated independently with development of PTSD in a multivariable analysis.

“In this retrospective study, ketamine administration was not a risk factor for the development of post-traumatic stress disorder in the military trauma setting,” the authors write.

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Mion G, Le Masson J, Granier C, Hoffmann C. A retrospective study of ketamine administration and the development of acute or post-traumatic stress disorder in 274 war-wounded soldiers [published online October 3, 2017]. Anaesthesia. doi:10.1111/anae.14079