A small pilot study suggests that methylphenidate may improve emotional and cognitive symptoms in patients with post-traumatic stress disorder (PTSD). Researchers reported their findings in Neuropsychopharmacology. 

Results from the 12-week, randomized, double-blind, placebo-controlled trial linked treatment with methylphenidate with statistically significant improvement on the Ruff Neurobehavioral Inventory-Postcomorbid Cognitive Scale, which assessed cognitive difficulties and was the study’s primary outcome. 

In addition, treatment with methylphenidate was associated with improvement in symptoms of concussion, as measured by then the Rivermead Post Concussive Symptom Questionnaire, and with improvement in PTSD symptoms, as measured by the Posttraumatic Stress Disorder Checklist. 

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