A new study in mice reveals that increased body weight and high blood sugar as a result of consuming a high-fat diet may cause anxiety and depressive symptoms and measurable changes in the brain.

Also, the beneficial effects of an antidepressant were blunted in mice fed a high-fat diet. On the other hand, taking mice off a high-fat diet completely reversed the animals’ metabolic impairments and lessened their anxious symptoms

The results set the tone for future investigations on potential mechanisms that may link metabolic and psychiatric disorders.

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