This rise in prescribing of prescription opioids in the last 2 decades of the 20th century occurred at a time during which medical professionals were urged to resort to prescription opioids to manage untreated and chronic noncancer pain.
Concurrent use of benzodiazepine receptor modulators and opioids and of nonselective and selective benzodiazepine receptor modulators increased from 1999-2000 to 2013-2014.
Investigators examined whether adolescents who use marijuana heavily develop acute psychotic symptoms at a much higher rate than youths who use marijuana minimally or not at all.
Changes in anxiety, depression, or insomnia symptoms were examined in patients with opioid use disorder taking extended-release naltrexone or buprenorphine-naloxone.
