The key findings of the study, conducted in the world’s largest BD cohort with genotypic and phenotypic data, offer potential sleep-related genetic underpinnings for BD diagnostic groups.
Patients with treatment resistant depression (TRD), defined as at least 3 treatment trials within a single depressive episode, were matched with 5 controls with non-treatment–resistant depression.
Comorbid anxiety worsened depressive symptom severity in general and was linked to suicidality.
Prescription opioid use among teens and young adults is higher than expected, with most obtaining the drugs from friends and family.
The usability of current electronic health records (EHRs) is classified as unacceptable, with physician-rated EHR usability independently linked to the odds of burnout.
The New Drug Application for viloxazine hydrochloride, a serotonin norepinephrine modulating agent, has been submitted to the FDA for the treatment of pediatric patients with ADHD.
Researchers aimed to identify factors related to depressive symptoms in ankylosing spondylitis and comprehend their underlying associations.
The long-term decrease in primary care contact was not interrupted following implementation of the Affordable Care Act.
Taking certain antidepressants while pregnant can increase the risk for developing gestational diabetes.
Sleep deprivation has more far-reaching effects on cognitive function than previously thought.
Two-thirds of parents acknowledge there are barriers to recognizing depression in their own adolescent child.
Prior research demonstrated that diagnostic differences in neural profiles were driven by region-of-interest analyses, which receded when only whole-brain analyses were considered.
Traditionally, suicide and overdose prevention in opioid use disorder involve stratifying risk based on certain demographic and clinical factors.
The risk for disability worsening is increased for individuals with multiple sclerosis (MS) and comorbid depression.
Hearing loss is associated with higher levels of anxiety, interpersonal sensitivity, and hostility, as well as higher rates of dementia, especially in older adults who are also visually impaired.
The Food and Drug Administration (FDA) has granted Fast Track designation to BNC210 (Bionomics Limited) for the treatment of post-traumatic stress disorder (PTSD) and other trauma-related and stressor-related disorders.
Overall, of 333 adult patients, 15.9% of patients reported opioid misuse, 17.1% were positive for PTSD, and 52.6% were positive for depression.
Mind-body therapies were linked with small declines in opioid dose, a promising finding in light of concerns surrounding the scale of opioid prescriptions in the United States.
Alzheimer disease patients who initiate treatment with antipsychotic medications spend more days hospitalized than those who do not initiate antipsychotics.
Reduced cortical thickness in the prefrontal cortex related to childhood obesity may result in compromised executive function.
Among patients who received stellate ganglion block (n=74), the adjusted mean CAP-5 total symptom severity score change from baseline was -12.6 points (95% CI, -15.5, -9.7 points) vs -6.1 points (95% CI, -9.8, -2.3 points) for those who received sham treatment.
The study emphasizes the necessity of further research concerning a treatment that is increasingly being legalized and applied to a wide range of medical conditions.
Investigators noted that the use of a healthy sample may limit generalizability, and the study’s sample overall had low levels of anxiety.
Researchers evaluated the efficacy of telephonic psychiatric evaluations and assessed their potential as a solution to meet the needs of asylum seekers.
Rachel Ochs-Ross, MD, a director at Janssen Research & Development in Titusville, New Jersey, and colleagues led a phase 3 double-blind randomized active-controlled multicenter trial of older adults.
The adjusted rate of opioid use increased nearly 4-fold (adjusted odds ratio, 4.18; 95% CI, 1.76-9.96), from 4.7% among new immigrants to 14.8% among those who had been in this country for 15 years or more.
Patients with Parkinson disease (PD) who use inappropriate antipsychotics may be at an increased risk for pneumonia compared with patients with PD who use more appropriate atypical antipsychotics.
Researchers conducted a multicenter randomized controlled trial of 214 veterans with PTSD from January 2012 through September 2013.
Higher levels of physical activity linked to reduced odds of depression, even with highest polygenic risk.
Pediatricians are likely to encounter children of undocumented parents during practice, making it essential for practitioners to be aware of the unique vulnerabilities faced by this population, as well as appropriate clinical procedure.
Child psychiatrists more likely to practice in high-income counties, metropolitan counties.
Cytokine markers IL-6 and IL-12 appeared to be sensitive to acute psychosocial stress in a laboratory setting.
Investigators at King’s College London and University College London in the UK abstracted data from 7026 twin pairs in the Twins Early Development Study (TEDS).
Overdose resulting from carfentanil ingestion may require larger doses of naloxone for successful resuscitation, according to a new case report.
According to the authors, this study distinguishes itself from others given its focus on cumulative exposure to cortisol rather than acute circulating levels.
Increased CBT efficacy was associated with younger age, greater initial severity of depression, individual administration format, and no concomitant use of antidepressants.
The authors examined 3 hypotheses: internalized stigma would be a stronger predictor of barriers to seeking mental health care than perceived stigma, alienation would be a stronger predictor of barriers than other components, and depression severity would modify the relationship of depression stigma and barriers to care.
From 2015 to 2017, number of opioid-involved overdose deaths increased for nearly all racial/ethnic groups.
For both patients with ulcerative colitis and those with Crohn disease, psychiatric diagnoses were more common in those who were elderly (greater than 65 years old), women, and white, and those with psychiatric conditions more frequently had a history of alcohol abuse, tobacco and substance abuse, personality disorder, and corticosteroid use.
The authors highlighted limitations, including the low quality of studies available based on the high risk of bias in RCTs and heterogeneity of the study designs.
For older adults, a higher rate of hospitalizations is associated with more rapid cognitive decline.
The odds of receiving an ADHD diagnosis were increased with having an eating disorder, depressive disorder, bipolar disorder, or anxiety disorder.
We surveyed HCPs about CBD to find out if and how the phytocannabinoid is affecting practices across America.
Although 11.0% of individuals taking antidepressants developed dementia, only 2.6% of the unexposed sample went on to be diagnosed with dementia.
Six goals include creation of positive work and learning environments that prevent, reduce burnout.
The investigators called for future studies to explore limits on daily social media use as a means of reducing mental health problems, as well as a balanced examination of the potential benefits and harms of social media use.
Higher risk for pain particularly seen for teen girls who experience posttraumatic stress.
Depression is a common comorbidity among patients with chronic pain, and the use of antidepressants may alleviate symptoms of both disorders.
Depression is linked to increased clinical burden in patients with COPD.
Cord biomarkers of in utero acetaminophen exposure tied to increased risk for childhood ADHD, ASD.