HealthDay News — Varenicline (Chantix) and bupropion (Wellbutrin) do not appear to increase the risk of mental health disorders such as depression, anxiety, and suicidal thoughts, according to a new study published online April 22 in The Lancet.

The research included 8144 individuals between the ages of 18 and 75 who smoked an average of more than 10 cigarettes per day and wanted to quit smoking. Half had a previous or current psychiatric condition, such as a mood, anxiety, psychotic, or borderline personality disorder, while about half of those participants were taking medications for their conditions. The participants were randomly assigned to 1 of 4 possible groups: varenicline, bupropion, nicotine patch, or  placebo. Patients were assessed for moderate to severe mental health problems such as agitation, aggression, panic, anxiety, depression, and suicidal thoughts during up to 3 months of treatment and at follow-up (up to 6 months).

Among those with no psychiatric disorders, there was no significant increase in the incidence of mental health issues in the 4 groups. While more mental health issues occurred among participants with psychiatric disorders, the rates were similar for all 4 groups. The researchers also examined quit rates and found that varenicline was the most effective. At follow-up, overall quit rates were: 21.8%, varenicline; 16.2%, bupropion; 15.7%, nicotine patches; and 9.4%, placebo. Quit rates were slightly lower for those with a psychiatric disorder.

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The study results “show that neuropsychiatric adverse events occurring during smoking cessation are independent of the medication used,” addiction expert Laurie Zawertailo, PhD, of the University of Toronto, writes in an accompanying editorial. “Clinicians should be comfortable prescribing the smoking cessation medication they feel would be most effective for their patient and should not worry about a specific medication increasing the risk of neuropsychiatric side effects.”

Funding for the research was provided by Pfizer (manufacturer of varenicline) and GlaxoSmithKline (manufacturer of bupropion).

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