Predictors of Optimal Schizophrenia Outcomes Using PP1M, PP3M Treatment

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Researchers sought to examine the most efficacious treatment for clinical remission in adults with schizophrenia.
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NEW ORLEANS — Paliperidone palmitate 1-month and 3-month (PP1M and PP3M) treatments have been linked to meaningful symptom improvement or remission in schizophrenia, according to research presented at the US Psych Congress, held September 16-19 in New Orleans, Louisiana. 

Researchers from Janssen Pharmaceuticals conducted a post-hoc analysis of a phase 3 trial ( identifier: NCT01515423) examining the efficacy of PP1M vs PP3M in treating adults with schizophrenia.

Study participants (n=411) included adults with a DSM-IV diagnosis of schizophrenia, a Positive and Negative Syndrome Scale (PANSS) score between 70 and 120, and worsening schizophrenia symptoms.

During the study’s open-label phase, participants received PP1M for 17 weeks (150 mg eq on day 1; 100 mg eq on day 8; flexible doses [50, 75, 100, or 150 mg at weeks 5 and 9 and a repeat of the week 9 dose at week 13). Patients considered clinically stable at weeks 14 and 17 were entered into the double-blind study phase and randomly assigned to receive 1:1 fixed doses of either PP1M (50, 75, 100, or 150 mg) or PP3M (175, 263, 350, or 525 mg).

At the conclusion of the double-blind period, 63.3% of patients receiving PP3M achieved remission, with “significantly greater” improvements in PANSS, Clinical Global Impression (CGI), and PSP measures.

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“Clinicians can obtain optimal clinical outcomes with PP3M by ensuring that their patients’ schizophrenia symptoms are well-managed for at least 12 weeks on PP1M prior to transition [to PP3M],” the researchers concluded.


Nash AI, Turkoz I, Savitz A, Matthews M, Kim E. Predictors of achieving remission in schizophrenia patients treated with paliperidone palmitate. Presented at: US Psych Congress; September 16-19, 2017; New Orleans, Lousiana.