|The following article is part of conference coverage from the 2018 American Psychiatric Association (APA) Annual Meeting in New York, New York. Psychiatry Advisor’s staff will be reporting breaking news associated with research conducted by leading experts in psychiatry. Check back for the latest news from APA 2018.|
NEW YORK – Deutetrabenazine (DTB) is associated with long-term improvements in abnormal movements for patients with tardive dyskinesia, per the results of a study presented at the 2018 American Psychiatric Association (APA) Annual Meeting, held May 5 to 9, 2018, in New York City.
Researchers developed an open-label safety study after 2 placebo-controlled, 12-week parent trials demonstrating the short-term efficacy and tolerability of DTB. Patients with tardive dyskinesia who had completed the DTB parent studies were eligible for the extension study after a 1-week washout period. Patients began the extension study at a baseline DTB dose of 12 mg/day, which was titrated during a 6-week period up to a maximum dose of 48 mg/day, based on dyskinesia control and individual tolerability.
Three site-rated efficacy measures were used: the Abnormal Involuntary Movement Scale (AIMS), the Clinical Global Impressions Scale (CGIC), and the Patients’ Global Impression of Change Scale (PGIC), each of which has applicability in real-world clinical practice settings.
At the end of the parent studies, patients treated with DTB experienced greater mean (standard error) improvements in AIMS score (−5.0) compared with patients given placebo (−3.2). After long-term DTB treatment in the extension study, both groups experienced improvements in AIMS score (prior DTB, −7.9; prior placebo, −6.6). At the end of the parent studies, a greater proportion of patients in the DTB group experienced treatment success on the CGIC (DTB, 51%; placebo, 32%) and the PGIC (DTB, 46%; placebo, 33%).
At week 54 of the extension study, treatment success was similar across parent groups for both the CGIC (prior DTB, 66%; prior placebo, 68%) and the PGIC (prior DTB, 62%; prior placebo, 62%). Trial investigators also reported that DTB was generally well tolerated during the extension study.
Patients treated with DTB showed long-term improvements in abnormal movements per 3 site-rated efficacy measures, which may have applicability in clinical practice settings. These results underscore the DTB efficacy reported in previous 12-week double-blind trials (ARM-TD and AIM-TD).
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Anderson K, et al. Long-term improvements in site-rated outcomes with deutetrabenazine treatment in patients with tardive dyskinesia. Presented at: . American Psychiatric Association (APA) Annual Meeting; New York, NY; May 5-9. Abstract 139.