Metabolic syndrome, including hypertension, obesity, dyslipidemia, and hyperglycemia, promote arterial stiffness, which has been linked to depression.
Overall, in all patients with MDD, sleep ultradian cycle number was positively associated with REMS percentage, REMS duration, and REMS/NREMS ratio and negatively associated with REM latency.
Mothers who have children with MS have a higher prevalence of physical conditions, as well as a higher prevalence of mood and anxiety disorders.
Cohort study data from 2018 to 2019 suggest poor compliance with the US Food and Drug Administration reporting requirements for clinical trial sponsors.
More teenagers are identifying as sexual minorities, and sexual minority youth have high prevalence of suicidal ideation, plans, and attempts.
Many older persons may have subthreshold depression, defined in the DSM-5 as depressed mood with at least 1 symptom of MDD and the presence of “clinically significant distress or deficit lasting at least 2 weeks.”
Maternal symptoms of depression in early pregnancy are slightly associated with lower levels of emotional availability.
The investigators sought to evaluate the effect of 50 mg or 100 mg of desvenlafaxine vs placebo on symptom cluster scores in patients with MDD, as well as the association between early improvement in symptom clusters and symptomatic or functional remission at 8 weeks.
The investigators sought to examine the importance of depression severity as a predictor of ECT use, as well as the risk for mortality, rehospitalization, and suicidal behavior, in a nationwide sample of patients with a first-time hospital diagnosis of major depression.
The investigators found no difference between BLT and sham/usual treatment in terms of the rates of remission from depressive episodes, changes in depressive symptom scores, and rates of manic switching.
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