Smoking increases the metabolism of clonidine through the CYP1A2, which may require the dose to be doubled to have the same plasma concentration as a non-smoker.
Schizophrenia Spectrum And Psychotic Disorders
Since publication of the last full practice guideline and guideline watch on schizophrenia, there have been a multitude of studies on new pharmacological and nonpharmacological treatments for schizophrenia.
Awareness of differences between psychosis in schizophrenia and bipolar disorder and varying presentations in patients can assist providers with diagnosis and treatment.
Emerging evidence has begun to elucidate the prevalence and outcomes associated with social anxiety disorder in schizophrenia.
Clinicians should be discerning when evaluating meta-analyses of schizophrenia add-on therapies such as statins and antidepressants.
“Since the current generation of psychiatrists has been raised on second-generation antipsychotics and has relatively little experience with first-generation antipsychotics, keeping tardive dyskinesia in mind is not, on the whole, part of their experience or training,” said Christoph U. Correll, MD.
A growing body of research consistently shows that patients with schizophrenia often suffer from sleep disturbances.
Understanding more about the original protocols of RCTs for various drugs may offer helpful insights into the clinical implications of those trials’ findings.