Generic Name and Formulations:
Angiotensin II 2.5mg/mL; per vial; soln for IV infusion after dilution.
La Jolla Pharmaceutical
Indications for GIAPREZA:
To increase blood pressure in septic or other distributive shock.
Give by IV infusion. Initially 20ng/kg/min. May titrate every 5mins by increments of up to 15ng/kg/min as needed based on BP response; max 80ng/kg/min during first 3hrs of treatment. Maintenance dose: max 40ng/kg/min. Doses as low as 1.25ng/kg/min may be used. Once sufficiently improved, down-titrate every 5–15mins by increments of up to 15ng/kg/min based on BP.
Risk of thrombosis. Use concurrent VTE prophylaxis. Pregnancy. Nursing mothers.
Concomitant ACE inhibitors may increase response. Concomitant ARBs may decrease response.
Thromboembolic events (eg, deep vein thrombosis), thrombocytopenia, tachycardia, fungal infection, delirium, acidosis, hyperglycemia, peripheral ischemia.
Single-dose vial (1mL, 2mL)—1
Sign Up for Free e-newsletters
Psychiatry Advisor Articles
- Nomophobia: The Modern-Day Pathology
- Emerging Theories in the Pathophysiology of MDD: Could the Opioid System Be Involved?
- Transdermal Nicotine Boosts Mood and Cognitive Function in Late-Life Depression
- Combination Cognitive Behavioral Therapy With Fluoxetine Effective for Adolescent Depression
- Prazosin May Be Effective as Treatment for Alcohol Use Disorder
- Text Message Reminders Improve Medication Adherence in Bipolar I Disorder
- Improving Medication Adherence in ADHD Lowers Risk for Oppositional Defiant Disorder, Conduct Disorder in Adulthood
- High Suicidality Among Children With ADHD Mediated by Family Functioning, Psychiatry Comorbidities
- Pilot Study Investigates Lithium vs Quetiapine for Bipolar Spectrum Disorder
- How Personalized Hospital Ratings May Drive Patient-Specific Care in the Digital Age