These findings suggest an urgent need for improved measures of social and clinical support in transgender and/or gender-nonconforming youth.
In a limited systematic review, hormonal therapy with gonadotropin-releasing hormone analogs (GnRHas) produced some suppression of secondary sexual function, with more success in promoting anticipated masculinization or feminization with the use of testosterone or estrogen, respectively.
Transgender and/or gender nonconforming children and adolescents had higher prevalence of mental health disorders compared to their cisgender peers.
Youth with gender nonconformity are vulnerable to experiencing adversity.
Endocrinologists reported having low confidence in their knowledge about caring for transgender patients.
This study highlights the need for policies and programs to reduce stigmatization and victimization of this population.
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