Generic Name and Formulations:
Isoflurane; liq for inhalation.
Indications for FORANE:
Induction and maintenance of general anesthesia.
Adults and Children:
See full labeling. Individualize. Induction: inspired concentrations of 1.5–3% isoflurane usually produce surgical anesthesia in 7–10 minutes. Maintenance: surgical levels of anesthesia may be sustained with a 1–2.5% concentration when nitrous oxide is used concomitantly. An additional 0.5–1% may be required when isoflurane is given using oxygen alone. If added relaxation is required, supplemental doses of muscle relaxants may be used.
Hypersensitivity to halogenated agents. Susceptibility to malignant hyperthermia.
To be administered only by those experienced in general anesthesia. Have intubation, artificial ventilation, oxygen and circulatory resuscitation available. Monitor for perioperative hyperkalemia esp. in pediatric patients during post-op period and those with latent or overt neuromuscular disease (eg, Duchenne muscular dystrophy); cardiac arrhythmias and death may occur. Pediatric neurotoxicity risk with repeated or prolonged use. Pregnancy. Nursing mothers.
Caution with desiccated CO2 absorbents; replace before administration. Hyperkalemia with succinylcholine. Potentiates effects of muscle relaxants, esp. nondepolarizing muscle relaxants. MAC reduced by concomitant nitrous oxide.
Respiratory depression, hypotension, arrhythmias, shivering, nausea, vomiting, ileus, transient elevations in CSF pressure, blood glucose, creatinine, cholesterol, ALK, WBC; perioperative hyperkalemia, malignant hyperthermia.
Bottles (100mL, 250mL)—1
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