Generic Name and Formulations:
Azelastine HCl, fluticasone propionate 137mcg/50mcg; per 0.137mL metered nasal spray; aqueous suspension.
Indications for DYMISTA:
Seasonal allergic rhinitis.
Adults and Children:
<6yrs: not established. ≥6yrs: 1 spray per nostril twice daily.
Avoid use in recent nasal ulcers, nasal surgery, or nasal trauma. Respiratory tract tuberculosis. Infections (eg, fungal, bacterial, viral, ocular herpes simplex). Avoid exposure to chickenpox and measles; if exposed, consider anti-infective prophylactic therapy. If adrenal insufficiency exists following systemic corticosteroid therapy, replacement with topical corticosteroids may exacerbate symptoms of adrenal insufficiency (eg, lassitude, depression). Monitor growth routinely in children. Monitor for hypercorticism and HPA axis suppression (if occur discontinue gradually), and Candida infection or other nasal mucosal changes. History of increased intraocular pressure, glaucoma, and/or cataracts; monitor any change in vision. Avoid eyes. Pregnancy (Cat.C). Nursing mothers: not recommended.
Avoid alcohol or other CNS depressants. Concomitant ritonavir: not recommended. Caution with other potent CYP3A4 inhibitors (eg, ketoconazole).
Antihistamine + corticosteroid.
Dysgeusia, epistaxis, headache; somnolence, vision changes.
Pump (23g)—120 sprays
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