Select therapeutic use:

Angina:

Indications for: TOPROL-XL

Angina pectoris.

Adult Dosage:

Initially 100mg once daily. May increase at 1-week intervals; max 400mg/day.

Children Dosage:

Not established.

TOPROL-XL Contraindications:

Severe bradycardia. 2nd- or 3rd-degree heart block. Cardiogenic shock. Decompensated heart failure. Sick sinus syndrome (unless paced).

TOPROL-XL Warnings/Precautions:

Mild or compensated heart failure. Ischemic heart or peripheral vascular disease. 1st-degree AV block. Sinus node dysfunction. Conduction disorders (eg, Wolff-Parkinson-White). Monitor HR during therapy. Bronchospastic disease. Pheochromocytoma. Surgery. Diabetes. Hypoglycemia. Hyperthyroidism. Avoid abrupt cessation. Hepatic impairment. Elderly. Neonates. Pregnancy. Nursing mothers: monitor infants.

TOPROL-XL Classification:

Beta-blocker.

TOPROL-XL Interactions:

May potentiate hypotension or marked bradycardia with catecholamine depleting drugs (eg, reserpine, MAOIs). Potentiated by strong CYP2D6 inhibitors (eg, quinidine, fluoxetine, paroxetine, propafenone); monitor if unavoidable. Increased risk of bradycardia with glycosides, clonidine, diltiazem, verapamil. May block epinephrine.

Adverse Reactions:

Fatigue, dizziness, depression, diarrhea, dyspnea, bradycardia, rash; heart block, MI, angina.

Generic Drug Availability:

YES

How Supplied:

Tabs—100, 1000

Pricing for TOPROL-XL

25mg tablet (Qty: 90)
Appx. price $20
GoodRx

CHF and arrhythmias:

Indications for: TOPROL-XL

Heart failure, to reduce the risk of cardiovascular mortality and heart failure hospitalizations in patients with heart failure.

Adult Dosage:

Class II: initially 25mg once daily; more severe: 12.5mg once daily. May double dose as tolerated every 2 weeks; reduce if symptomatic bradycardia occurs; max 200mg/day.

Children Dosage:

Not established.

TOPROL-XL Contraindications:

Severe bradycardia. 2nd- or 3rd-degree heart block. Cardiogenic shock. Decompensated heart failure. Sick sinus syndrome (unless paced).

TOPROL-XL Warnings/Precautions:

Mild or compensated heart failure. Ischemic heart or peripheral vascular disease. 1st-degree AV block. Sinus node dysfunction. Conduction disorders (eg, Wolff-Parkinson-White). Monitor HR during therapy. Bronchospastic disease. Pheochromocytoma. Surgery. Diabetes. Hypoglycemia. Hyperthyroidism. Avoid abrupt cessation. Hepatic impairment. Elderly. Neonates. Pregnancy. Nursing mothers: monitor infants.

TOPROL-XL Classification:

Beta-blocker.

TOPROL-XL Interactions:

May potentiate hypotension or marked bradycardia with catecholamine depleting drugs (eg, reserpine, MAOIs). Potentiated by strong CYP2D6 inhibitors (eg, quinidine, fluoxetine, paroxetine, propafenone); monitor if unavoidable. Increased risk of bradycardia with glycosides, clonidine, diltiazem, verapamil. May block epinephrine.

Adverse Reactions:

Fatigue, dizziness, depression, diarrhea, dyspnea, bradycardia, rash; heart block, MI, angina.

Generic Drug Availability:

YES

How Supplied:

Tabs—100, 1000

Pricing for TOPROL-XL

25mg tablet (Qty: 90)
Appx. price $20
GoodRx

Hypertension:

Indications for: TOPROL-XL

Hypertension.

Adult Dosage:

Initially 25–100mg once daily, alone or with a diuretic. May increase at 1-week intervals; max 400mg/day.

Children Dosage:

<6yrs: not established. ≥6yrs: initially 1mg/kg once daily; max 50mg/day. Adjust based on response. Max 2mg/kg (200mg) daily.

TOPROL-XL Contraindications:

Severe bradycardia. 2nd- or 3rd-degree heart block. Cardiogenic shock. Decompensated heart failure. Sick sinus syndrome (unless paced).

TOPROL-XL Warnings/Precautions:

Mild or compensated heart failure. Ischemic heart or peripheral vascular disease. 1st-degree AV block. Sinus node dysfunction. Conduction disorders (eg, Wolff-Parkinson-White). Monitor HR during therapy. Bronchospastic disease. Pheochromocytoma. Surgery. Diabetes. Hypoglycemia. Hyperthyroidism. Avoid abrupt cessation. Hepatic impairment. Elderly. Neonates. Pregnancy. Nursing mothers: monitor infants.

TOPROL-XL Classification:

Cardioselective beta-blocker.

TOPROL-XL Interactions:

May potentiate hypotension or marked bradycardia with catecholamine depleting drugs (eg, reserpine, MAOIs). Potentiated by strong CYP2D6 inhibitors (eg, quinidine, fluoxetine, paroxetine, propafenone); monitor if unavoidable. Increased risk of bradycardia with glycosides, clonidine, diltiazem, verapamil. May block epinephrine.

Adverse Reactions:

Fatigue, dizziness, depression, diarrhea, dyspnea, bradycardia, rash; heart block, MI, angina.

Generic Drug Availability:

YES

How Supplied:

Tabs—100, 1000

Pricing for TOPROL-XL

25mg tablet (Qty: 90)
Appx. price $20
GoodRx