• Hereditary angioedema

Hereditary angioedema:

Indications for TAKHZYRO:

Prophylaxis to prevent attacks of hereditary angioedema (HAE).

Adult:

Give by SC inj into abdomen, thigh, or upper arm. Initially 300mg every 2 weeks. May consider 300mg every 4 weeks if well-controlled (eg, attack free) for >6 months.

Children:

<12yrs: not established.

Warnings/Precautions:

Discontinue and treat if severe hypersensitivity reaction occurs. Pregnancy (during 3rd trimester). Nursing mothers.

Pharmacologic Class:

Plasma kallikrein inhibitor.

Interactions:

May increase activated partial thromboplastin time (aPTT) on assay.

Adverse Reactions:

Inj site reactions, upper respiratory infections, headache, rash, myalgia, dizziness, diarrhea; hypersensitivity, increased AST/ALT.

Generic Availability:

NO

How Supplied:

Single-dose vial—1