Diabetes:

Indications for RYBELSUS:

As adjunct to diet and exercise, to improve glycemic control in adults with type 2 diabetes mellitus (T2DM).

Limitations of Use:

Not recommended as first-line therapy for patients inadequately controlled on diet and exercise. Not studied with a history of pancreatitis. Not for treating type 1 diabetes or diabetic ketoacidosis.

Adult:

Swallow whole. Take at least 30mins before first food, beverage, or other oral medications with max 4oz of plain water only. ≥18yrs: Initially 3mg once daily for 30 days, then increase to 7mg once daily; may increase to 14mg once daily if additional glycemic control needed after ≥30 days on 7mg dose. Taking two 7mg tabs to achieve a 14mg dose: not recommended. Switching between Ozempic and Rybelsus: see full labeling.

Children:

<18yrs: not established.

Contraindications:

History (personal or family) of medullary thyroid carcinoma. Multiple endocrine neoplasia syndrome type 2.

Boxed Warning:

Risk of thyroid C-cell tumors.

Warnings/Precautions:

Risk of thyroid C-cell tumors; inform patients of potential risk and symptoms. History of pancreatitis; consider other antidiabetics. Monitor for pancreatitis; discontinue if suspected; do not restart if confirmed. History of diabetic retinopathy; monitor for progression. Monitor renal function when initiating or escalating dose. History of anaphylaxis or angioedema with other GLP-1 receptor agonist. Discontinue if hypersensitivity reactions occur. Pregnancy. Females of reproductive potential: discontinue ≥2 months prior to planned pregnancy. Nursing mothers: not recommended.

Pharmacologic Class:

Glucagon-like peptide-1 (GLP-1) receptor agonist.

Interactions:

Increased risk of hypoglycemia with concomitant insulin secretagogues (eg, sulfonylureas) or insulin; may need lower dose of these. May affect absorption of concomitant oral drugs (delayed gastric emptying); caution.

Adverse Reactions:

Nausea, abdominal pain, diarrhea, decreased appetite, vomiting, constipation; rare: pancreatitis, hypersensitivity reactions.

Generic Availability:

NO

How Supplied:

Tabs—30

Pricing for RYBELSUS

30 tablets of 7mg carton (Qty: 1)
Appx. price $844
GoodRx