Select therapeutic use:

Asthma/COPD:

Indications for NUCALA:

Add-on maintenance treatment of severe asthma in patients ≥6yrs old, and with an eosinophilic phenotype.

Limitations of Use:

Not for relief of acute bronchospasm or status asthmaticus.

Adults and Children:

<6yrs: not established. Give by SC inj into upper arm, thigh, or abdomen. 6–11yrs (use vials only): 40mg once every 4 weeks. ≥12yrs: 100mg once every 4 weeks.

Warnings/Precautions:

Not for treating acute asthma symptoms or exacerbations. Opportunistic infections (eg, herpes zoster); consider varicella vaccination if appropriate. Treat pre-existing helminth infections prior to initiation; discontinue Nucala if treatment-resistant infection occurs while on therapy until resolves. Avoid abrupt discontinuation of systemic or inhaled corticosteroids; reduce dose gradually upon Nucala initiation. Reduction may be associated with systemic withdrawal symptoms and/or unmask previously suppressed conditions. Elderly. Pregnancy. Nursing mothers.

Pharmacologic Class:

Interleukin-5 antagonist.

Adverse Reactions:

Headache, inj site reactions, back pain, fatigue; infections, hypersensitivity reactions (discontinue if occur); possible antibody formation.

Generic Availability:

NO

How Supplied:

Single-dose vial—1; Single-dose prefilled syringe—1 (w. needle); Single-dose autoinjector—1 (w. needle)

Pricing for NUCALA

100mg vial (Qty: 1)
Appx. price $3523
GoodRx

Miscellaneous immune disorders:

Indications for NUCALA:

Eosinophilic granulomatosis with polyangiitis (EGPA) in adults.

Adult:

Give by SC inj into upper arm, thigh, or abdomen. ≥18yrs: 300mg (as three separate 100mg inj) once every 4 weeks; inject at least 2 inches apart if at the same site.

Children:

<18yrs: not established.

Warnings/Precautions:

Not for treating acute asthma symptoms or exacerbations. Opportunistic infections (eg, herpes zoster); consider varicella vaccination if appropriate. Treat pre-existing helminth infections prior to initiation; discontinue Nucala if treatment-resistant infection occurs while on therapy until resolves. Avoid abrupt discontinuation of systemic or inhaled corticosteroids; reduce dose gradually upon Nucala initiation. Reduction may be associated with systemic withdrawal symptoms and/or unmask previously suppressed conditions. Elderly. Pregnancy. Nursing mothers.

Pharmacologic Class:

Interleukin-5 antagonist.

Adverse Reactions:

Headache, inj site reactions, back pain, fatigue; infections, hypersensitivity reactions (discontinue if occur); possible antibody formation.

Generic Availability:

NO

How Supplied:

Single-dose vial—1; Single-dose prefilled syringe—1 (w. needle); Single-dose autoinjector—1 (w. needle)

Pricing for NUCALA

100mg vial (Qty: 1)
Appx. price $3523
GoodRx