Hyperlipoproteinemias:
Indications for NEXLETOL:
An adjunct to diet and maximally tolerated statin therapy, in patients with heterozygous familial hypercholesterolemia or established atherosclerotic cardiovascular disease who require additional lowering of LDL-C.
Limitations of Use:
The effect of Nexletol on cardiovascular morbidity and mortality has not been determined.
Adult:
180mg once daily.
Children:
Not established.
Warnings/Precautions:
Hyperuricemia. Assess serum uric acid as clinically indicated. History of gout. Increased risk for tendon rupture/injury (esp. >60yrs, renal failure); discontinue immediately if occurs; consider discontinuing if joint pain, swelling, or inflammation develop. History of tendon disorders/rupture: consider alternative therapy. Assess lipid levels within 8–12 weeks after initiation. Elderly. Severe hepatic (Child-Pugh C) or renal impairment (eGFR <30mL/min/1.73 m2). ESRD on dialysis. Pregnancy: discontinue if occurs. Nursing mothers: not recommended.
Pharmacologic Class:
Adenosine triphosphate-citrate lyase (ACL) inhibitor.
Interactions:
Avoid concomitant simvastatin >20mg or pravastatin >40mg. Increased risk for tendon rupture with corticosteroid or fluoroquinoline drugs.
Adverse Reactions:
Upper respiratory tract infection, muscle spasms, hyperuricemia, back pain, abdominal pain or discomfort, bronchitis, pain in extremity, anemia, elevated liver enzymes; gout, BPH.
Generic Availability:
NO
How Supplied:
Tabs—30, 90
