Constipation and bowel cleansers:
Indications for MOTEGRITY:
Chronic idiopathic constipation (CIC) in adults.
≥17yrs: 2mg once daily. Severe renal impairment (CrCl <30mL/min): 1mg once daily.
<17yrs: not established.
Intestinal perforation or obstruction due to structural or functional disorder of the gut wall, obstructive ileus, or severe inflammatory conditions of the intestinal tract (eg, Crohn’s disease, ulcerative colitis, toxic megacolon/megarectum).
Monitor for worsening depression or emergence of suicidal thoughts and behaviors; discontinue if occurs. Elderly: adjust dose based on renal function. ESRD requiring dialysis: not recommended. Pregnancy. Nursing mothers.
Selective 5-HT4 receptor agonist.
Headache, abdominal pain, nausea, diarrhea, abdominal distension, dizziness, vomiting, flatulence, fatigue; suicidal ideation/behavior.