Imaging agents:

Indications for LUMASON:

In adults and children with suboptimal echocardiograms to opacify the left ventricular chamber and to improve the delineation of the left ventricular endocardial border. In ultrasonography of the liver to characterize focal liver lesions in adults and children. In ultrasonography of the urinary tract for evaluation of suspected or known vesicoureteral reflux in children.

Adult Dosage:

See full labeling. Echocardiography: 2mL via IV bolus inj. Ultrasonography of the liver: 2.4mL via IV inj. Both: may repeat dose once if needed. Follow each inj with 5mL normal saline flush.

Children Dosage:

See full labeling. Echocardiography: 0.03mL/kg via IV inj; max 2mL per inj. Ultrasonography of the liver: 0.03mL/kg via IV inj; max 2.4mL per inj. Both: may repeat dose once if needed. Follow each inj with 5mL normal saline flush. Ultrasonography of the urinary tract: 1mL via intravesical bolus inj through the urinary catheter. The bladder may be refilled with normal saline for second cycle of voiding and imaging, without the need of a second Lumason inj.

Boxed Warning:

Serious cardiopulmonary reactions.

LUMASON Warnings/Precautions:

Do not administer by intra-arterial inj. Risk of serious cardiopulmonary reactions; increased risk in those with unstable conditions (eg, acute MI, coronary artery syndromes, CHF, ventricular arrhythmias). Have resuscitation equipment and trained personnel readily available. Monitor for hypersensitivity reactions. Assess for prior hypersensitivity to PEG (eg, bowel preps, laxatives). Assess patients with cardiac shunts for embolic phenomena post inj. Not recommended for use at mechanical indices >0.8; high index values may lead to ventricular arrhythmias. Pregnancy. Nursing mothers.

LUMASON Classification:

Contrast media.

Adverse Reactions:

Headache, nausea, dysgeusia, inj site pain, feeling hot; cardiopulmonary reactions, anaphylaxis.

Generic Drug Availability:

NO

How Supplied:

Kit—1 (one vial + diluent + mini-spike)