• Melanoma and other skin cancers

Melanoma and other skin cancers:

Indications for LIBTAYO:

Treatment of metastatic cutaneous squamous cell carcinoma (CSCC) or locally advanced CSCC in patients who are not candidates for curative surgery or curative radiation.

Adult:

Give by IV infusion over 30mins. 350mg every 3 weeks until disease progression or unacceptable toxicity. Dose modifications for adverse reactions: see full labeling.

Children:

Not established.

Warnings/Precautions:

Monitor for immune-related pneumonitis, colitis, hepatitis, endocrinopathies (adrenal insufficiency, hypophysitis, thyroid disorders, diabetes), nephritis, dermatologic, others; see full labeling. Evaluate clinical chemistries, including liver and thyroid function tests at baseline and periodically during treatment. Manage promptly as appropriate. Withhold for Grade 3 or 4 and certain Grade 2 immune-related adverse reactions. Permanently discontinue for Grade 4 or certain Grade 3 immune-related adverse reactions. Administer corticosteroids or consider other systemic immunosuppressants to control immune-related reactions until resolved. Institute hormone replacement therapy for endocrinopathies as needed. Monitor for infusion-related reactions; interrupt or slow infusion rate or permanently discontinue based on reaction severity. Embryo-fetal toxicity. Females of reproductive potential should use effective contraception during and for ≥4 months after the last dose. Pregnancy: exclude status prior to initiation. Nursing mothers: not recommended (during and for ≥4 months after the last dose).

Pharmacologic Class:

Human programmed death receptor-1 (PD-1)-blocking antibody.

Adverse Reactions:

Fatigue, rash, diarrhea, nausea, musculoskeletal pain, pruritus, constipation, decreased appetite; other immune-mediated adverse reactions (eg, neurological, cardiovascular, ocular, gastrointestinal, musculoskeletal and connective tissue, hematological, immunological).

Generic Availability:

NO

How Supplied:

Single-dose vial—1

Pricing for LIBTAYO

7ml of 50mg/ml vial (Qty: 1)
Appx. price $9009
GoodRx