Indications for KEFLEX:
Susceptible infections including otitis media, skin and skin structure, bone, respiratory or genitourinary tract.
≥15yrs: usually 250mg every 6hrs; may give 500mg every 12hrs. Treat for 7–14 days. Severe infections: up to 4g/day in 2–4 equally divided doses. Renal impairment (CrCl 30–59mL/min): max 1g/day; (CrCl 15–29mL/min): 250mg every 8hrs or 12hrs; (CrCl 5–14mL/min, no dialysis): 250mg every 24hrs; (CrCl 1–4mL/min, no dialysis): 250mg every 48hrs or 60hrs.
Give in equally divided doses. >1yr: 25–50mg/kg/day. Treat for 7–14 days. β-hemolytic strep: treat for ≥10 days. Severe infections: 50–100mg/kg/day. Otitis media: 75–100mg/kg/day.
Penicillin or other allergy. Risk of seizures (esp. in renal impairment); discontinue if occurs. Poor nutritional state. Renal impairment (CrCl <30mL/min, with or without dialysis): monitor. Pregnancy. Nursing mothers.
Concomitant probenecid: not recommended. Potentiates metformin (monitor and adjust metformin dose). May cause false (+) glucose test with Benedict's or Fehling's soln.
GI upset, abdominal pain; hypersensitivity reactions (discontinue if occur), C. difficile-associated diarrhea, hemolytic anemia. positive Coombs' test, prolonged prothrombin time (monitor).
Caps 250mg, 500mg—100; 750mg—50