Glaucoma:

Indications for IOPIDINE 1%:

To control or prevent post-surgical elevations in IOP after argon laser trabeculoplasty or iridotomy, or Nd:YAG posterior capsulotomy.

Adult:

Instill 1 drop into operative eye 1hr before laser surgery and a second drop immediately after procedure is completed.

Children:

Not established.

Contraindications:

Clonidine allergy. Concomitant MAOIs.

Warnings/Precautions:

Monitor visual fields. Severe uncontrolled cardiovascular disease, hypertension, coronary insufficiency. Recent myocardial infarction. Cerebrovascular disease. Raynaud's disease. Thromboangiitis obliterans. History of vasovagal attack. Discontinue if ocular allergic-like reactions occur. Renal or hepatic impairment: closely monitor cardiovascular parameters. Depression. May mask hypoglycemia. Pregnancy. Nursing mothers (1% soln: discontinue nursing temporarily for 1 day of use).

See Also:

Pharmacologic Class:

Alpha-2 agonist.

Interactions:

See Contraindications. May potentiate CNS depressants (eg, alcohol, barbiturates, opiates, sedatives, anesthetics). Caution with TCAs, β-blockers, antihypertensives, cardiac glycosides, others (eg, clonidine). Concomitant CV drugs: monitor HR, BP periodically.

Adverse Reactions:

Hyperemia, pruritus, dry mouth, itching, discomfort, tearing, dizziness, solmnolence, lid edema, blurred vision, foreign body sensation, dry eye, conjunctivitis, discharge, blanching; tachyphylaxis may develop after 1 month; also in post-laser surgery: upper lid elevation, inflammation, nasal decongestion, mydriasis, irregular HR.

How Supplied:

Soln 0.5%—contact supplier; 1% (0.1mL)—2