Indications for HYPERRAB:

Postexposure prophylaxis of rabies (along with rabies vaccine).


See full labeling. Give by IM inj preferably at the time of 1st vaccine dose; may be given through 7th day after 1st vaccine dose is given. Not previously vaccinated: 20 IU/kg (0.0665mL/kg) once. If feasible, up to full dose should be infiltrated in area around wound and the rest (if any) into deltoid muscle of upper arm or lateral thigh muscle.


Not established.


Previously immunized with rabies vaccine with a confirmed adequate rabies antibody titer: not recommended. Contains human plasma; monitor for possible infection transmission. IgA-deficiency. Prior history of allergic reactions to human immunoglobulins. Have epinephrine inj available. Pregnancy. Nursing mothers.

Pharmacologic Class:

Immune globulin.


Do not administer repeated doses after administration of rabies vaccine; may suppress immune response to the vaccine. Avoid live vaccines for 4 months (eg, measles, mumps, polio, rubella).

Adverse Reactions:

Inj site pain or nodule, headache, abdominal pain, diarrhea, flatulence, nasal congestion, oropharyngeal pain; hypersensitivity reactions.

Generic Availability:


How Supplied:

Single-dose vial (1mL, 3mL, 5mL)—1