Indications for Chlorpropamide:
Adjunct to diet in type 2 diabetes.
Initially 250mg daily. Elderly: initially 100–125mg daily. Titrate dose. Take with breakfast. Max 750mg daily.
Type 1 diabetes mellitus. Diabetic ketoacidosis.
Oral hypoglycemic agents may increase risk of cardiovascular mortality. Impaired renal or hepatic function. Adrenal or pituitary insufficiency. Stress. Secondary failure may occur with extended therapy. G6PD deficiency. Monitor urine and blood glucose. Discontinue if jaundice or persistent rash occurs. Malnourished. Elderly. Debilitated. Pregnancy (Cat.C): consider insulin instead. Nursing mothers: not recommended.
Sulfonylurea (1st generation).
Potentiated by NSAIDs, alcohol, highly protein bound drugs, salicylates, sulfonamides, chloramphenicol, probenecid, coumarins, MAOIs, β-blockers. Antagonized by diuretics, steroids, phenothiazines, thyroid products, phenytoin, niacin, sympathomimetics, calcium channel blockers and isoniazid. Disulfiram-like reaction with alcohol.
Hypoglycemia, cholestatic jaundice, GI disturbances, allergic skin reactions, photosensitivity, blood dyscrasias, hepatic porphyria.
Formerly known under the brand name Diabinese.