Muscle spasms:
Indications for Cyclobenzaprine HCl Tablets:
Relief of acute muscle spasm, as adjunct to rest and physical therapy.
Adult:
≥15yrs: initially 5mg 3 times daily, may increase to 10mg 3 times daily; max 2–3 weeks. Elderly or mild hepatic impairment: initially 5mg and then titrate slowly upward.
Children:
<15yrs: not established.
Contraindications:
Acute post-MI. Arrhythmias, heart block, other conduction disturbances. CHF. Hyperthyroidism. During or within 14 days of MAOIs.
Warnings/Precautions:
Moderate-to-severe hepatic impairment: not recommended. Urinary retention. Glaucoma. Increased intraocular pressure. Elderly. Pregnancy (Cat.B). Nursing mothers.
Pharmacologic Class:
Muscle relaxant (central).
Interactions:
See Contraindications. Hypertensive crisis with MAOIs. Increased risk of serotonin syndrome with other serotonergic drugs (eg, SSRIs, SNRIs, tricyclic antidepressants, tramadol, bupropion, meperidine, verapamil, or MAOIs); monitor closely. Potentiates anticholinergics, alcohol, other CNS depressants. May antagonize guanethidine, clonidine. Tramadol increases seizure risk.
Adverse Reactions:
Drowsiness, dry mouth, dizziness, fatigue, headache, GI upset, asthenia, irritability, nervousness, blurred vision, confusion, arrhythmias, tachycardia, hypotension.
Note:
Formerly known under the brand names Flexeril, Fexmid.
How Supplied:
Contact supplier.
