Miscellaneous hematological agents:

Indications for CEPROTIN:

Prevention and treatment of venous thrombosis and purpura fulminans in severe congenital Protein C deficiency.

Adults and Children:

Give by IV infusion only. <10kg: max rate 0.2mL/kg/min; ≥10kg: max rate 2mL/min. Individualize. Acute episodes/short term prophylaxis: initially 100–120 IU/kg, then 60–80 IU/kg every 6hrs for 3 doses (adjust dose to maintain target peak protein C activity of 100%); maintenance: 45–60 IU/kg every 6 or every 12hrs (maintain trough protein C level above 25% for duration of therapy); continue until desired anticoagulation achieved. Long-term prophylaxis: 45–60 IU/kg every 12hrs (maintain trough protein C level above 25%). Switching to oral anticoagulants: start with low dose; continue protein C replacement until stable anticoagulation obtained.

Warnings/Precautions:

Measure protein C activity before and during treatment; if acute thrombotic event occurs, obtain protein C activity measurement before the next injection until patient is stable. Contains human albumin; monitor for possible viral disease and Creutzfeldt-Jakob disease transmission. Mouse protein allergy. Contains heparin; if heparin-induced thrombocytopenia suspected, check platelet counts immediately, consider discontinuing. Renal impairment and/or sodium-restricted (max daily dose contains sodium >200mg). Labor & delivery. Pregnancy. Nursing mothers.

Pharmacologic Class:

Anticoagulant protein.

Interactions:

Increased risk of bleeding with concurrent anticoagulants, tissue plasminogen activator.

Adverse Reactions:

Rash, itching, lightheadedness; hypersensitivity reactions (discontinue if occurs).

Note:

Report all infections suspected to be transmitted by Ceprotin to (866) 888-2472.

How Supplied:

Single-use vial—1 (w. diluent, supplies)