Indications for AVONEX:
Relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease.
Pre-medicate with analgesics and/or antipyretics on treatment days to ameliorate flu-like symptoms. Rotate inj sites. ≥18yrs: 30mcg IM once weekly. May titrate dose to reduce severity of flu-like symptoms; dosed once weekly, IM: Week 1: 7.5mcg. Week 2: 15mcg. Week 3: 22.5mcg. Week 4: 30mcg.
<18yrs: not established.
Depression. Suicidal ideation. Pre-existing psychiatric disorders (eg, psychosis). Seizure disorders. Monitor for hepatic injury. Pre-existing CHF: monitor for worsening cardiac function at initiation and during treatment. Risk of thrombotic microangiopathy; discontinue if occurs. Myelosuppression. Monitor CBCs, differential, platelets, blood chemistries, liver and thyroid function. Consider discontinuing if new autoimmune disorder develops. Latex allergy. Pregnancy. Nursing mothers.
Risk of hepatic injury with concomitant hepatotoxic drugs or alcohol.
Flu-like symptoms, asthenia, headache, myalgia, fever, chills, GI upset, depression, blood dyscrasias, seizures; rare: hepatic injury, anaphylaxis (discontinue if occurs).
Register pregnant patients exposed to Avonex by calling (800) 456-2255.
Half-life: 19 hours.
Single-use prefilled syringe, autoinjector (Avonex Pen)—1, 4 (w. supplies)