Indications for AMIDATE:
For the induction of general anesthesia. For the supplementation of subpotent anesthetic agents (eg, nitrous oxide in oxygen) during maintenance of anesthesia for short operative procedures (eg, dilation and curettage, cervical conization).
Adults and Children:
<10yrs: not recommended. Induction: Give by IV inj over 30–60 seconds. ≥10yrs: Individualize. Usual range: 0.2–0.6mg/kg. Usual dose: 0.3mg/kg. Elderly: may need to reduce dose. Supplementation: smaller increments may be given.
To be administered only by those experienced in general anesthesia. May reduce plasma cortisol and aldosterone concentrations; consider exogenous replacement in patients undergoing severe stress. Pediatric neurotoxicity risk with repeated or prolonged use. Renal impairment. Elderly (may induce cardiac depression). Labor & delivery: not recommended. Pregnancy (Cat.C). Nursing mothers.
Concomitant IV fentanyl and other neuroactive drugs; may need to adjust etomidate dose.
Transient venous pain on inj, transient skeletal muscle movements including myoclonus, hyper- or hypoventilation, apnea, laryngospasm, hiccup, snoring, hyper- or hypotension, tachycardia, arrhythmias, post-op nausea/vomiting.
Generic Drug Availability:
Vial—10mL, 20mL; Ampul—10mL, 20mL; Abboject syringe—20mL