• Miscellaneous immune disorders

Miscellaneous immune disorders:

Indications for RUZURGI:

Lambert-Eaton myasthenic syndrome (LEMS) in patients 6 to <17yrs of age.

Adult:

Not applicable.

Children:

<6yrs: not established. 6–<17yrs: (≥45kg): initially 15–30mg daily in 2–3 divided doses, may increase daily by 5–10mg increments, divided in up to 5 doses; max single dose: 30mg; max total maintenance 100mg/day; (<45kg): initially 7.5–15mg daily in 2–3 divided doses, may increase daily by 2.5–5mg increments, divided in up to 5 doses; max single dose: 15mg; max total maintenance 50mg/day. Hepatic or renal impairment (CrCl 15–90mL/min), NAT2 poor metabolizers: (≥45kg): initially 15mg daily in divided doses; (<45kg): initially 7.5mg daily in divided doses.

Contraindications:

History of seizures.

Warnings/Precautions:

Consider dose reduction or discontinuation if seizure occurs. Discontinue and treat if anaphylaxis occurs. Hepatic or renal impairment: monitor; adjust dose or discontinue as needed. N-acetyltransferase 2 (NAT2) poor metabolizers. Pregnancy. Nursing mothers.

Pharmacologic Class:

Potassium channel blocker.

Interactions:

Concomitant drugs that lower seizure threshold may increase seizure risk. Additive effects when concomitant drugs with cholinergic effects (eg, direct or indirect cholinesterase inhibitors).

Adverse Reactions:

Paresthesia/dysesthesia, abdominal pain, dyspepsia, dizziness, nausea; seizures, hypersensitivity.

Generic Availability:

NO

How Supplied:

Tabs—100

Pricing for RUZURGI

10mg tablet (Qty: 30)
Appx. price $2384
GoodRx