Generic Name and Formulations:
Deferoxamine mesylate 250mg/mL; for inj after reconstitution.
Novartis Pharmaceuticals Corp
Indications for DESFERAL:
Acute iron intoxication. Chronic iron overload due to multiple transfusions.
Adults and Children:
Routes other than IM: see literature. <3yrs: not recommended. ≥3yrs: acute iron toxicity: 1g IM initially followed by 500mg every 4 hours for 2 doses; repeat every 4–12 hours if needed; max 6g/day. Chronic iron overload: see literature.
Severe renal disease. Anuria.
Ocular or auditory disturbances. Perform visual acuity tests, slit-lamp exams, funduscopy and audiometry with prolonged therapy. High doses in patients with low ferritin levels may retard growth. Acute respiratory distress syndrome with high IV doses. Flushing, urticaria, hypotension, and shock if given rapid IV. Monitor changes in renal function. Discoloration of urine. Elderly. Pregnancy (Cat.C). Nursing mothers.
Iron chelating agent.
Possible impairment of cardiac function with concomitant high dose Vit. C; give max adult dose: 200mg in divided doses. May cause temporary impairment of consciousness with prochlorperazine.
Localized skin reactions, hypersensitivity, tachycardia, hypotension, shock, dysuria, leg cramps, fever, GI upset; increased serum creatinine, acute renal failure, renal tubular disorder; rare: Yersinia infections, mucormycosis.
Sign Up for Free e-newsletters
Psychiatry Advisor Articles
- Age of Onset of Bipolar Disorder Linked With Substance Use Disorders
- Low Testosterone Linked With Social Anxiety in Boys With Klinefelter Syndrome
- Posttraumatic Stress Disorder Associated With Reduced Brain Volume
- First-Episode Drug-Naive Patients With Schizophrenia More Likely to Attempt Suicide
- ADHD Medications Compared for Efficacy, Tolerability in Children and Adults
- The Psychology of Hoarding Disorder: Approaches for Treatment
- Mind-Body Therapy and Psychiatry: Ancient Tools for Modern Practice
- Smartphone Applications for Depression and Anxiety: Are They Ready for Widespread Use?
- The Many Misconceptions of Catatonia: Treatment Is Often Successful With the Right Knowledge
- Marijuana Use Associated With Poorer Depression Outcomes, Increased Suicidal Ideation