Depressive Disorders

Psychosocial Intervention Improves Early Adherence to Antidepressants

Psychosocial Intervention Improves Early Adherence to Antidepressants

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Early adherence is an especially problematic, significant and modifiable barrier to quality care for depression.

Risk of Anxiety Disorder Relapse After Discontinuing Antidepressants

Risk of Anxiety Disorder Relapse After Discontinuing Antidepressants

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Researchers examined whether the risk of relapse or time to relapse was related to type of anxiety disorder, duration of previous treatment, and other factors.

Anxiety and Depression's Effect on BMD in Anorexia

Anxiety and Depression's Effect on BMD in Anorexia

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Scores for both anxiety and depression are associated with low BMD.

Depression, Anxiety May Affect Bone Metabolism in Young Adults

Depression, Anxiety May Affect Bone Metabolism in Young Adults

In young adults, MDD, GAD, and SSRI use is associated with bone metabolism.

Cytokine Levels May Predict SSRI Response in Children and Adolescents

Cytokine Levels May Predict SSRI Response in Children and Adolescents

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Elevated cytokine levels could help to identify children who are unlikely to respond to treatment with fluoxetine.

Executive Dysfunction in Idiopathic Depression vs Epilepsy-associated Depression

Executive Dysfunction in Idiopathic Depression vs Epilepsy-associated Depression

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Individuals suffering from depression, as well as persons diagnosed with temporal lobe epilepsy, present with dysfunction across several cognitive domains.

Cigarette Smoking Predicts Development of Depression

Cigarette Smoking Predicts Development of Depression

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Cigarette smoking prevalence among persons with severe mental illness is approximately 3 times greater than the rate observed in the general population.

Depressive Symptoms Linked to Shorter Survival With Lung Cancer

Depressive Symptoms Linked to Shorter Survival With Lung Cancer

Depression symptoms at baseline correlated with increased mortality among participants with early- but not late-stage disease.

Sertraline Prevents Depression Following Traumatic Brain Injury

Sertraline Prevents Depression Following Traumatic Brain Injury

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Approximately 80% of depressive episodes have their onset during the first six months following traumatic brain injury.

Pupillometric Analysis For Assessment of Depression Recurrence

Pupillometric Analysis For Assessment of Depression Recurrence

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Pupillary reactivity to emotional stimuli has been investigated to provide objective information about the risk for recurrence of depressive symptoms in women.

Mood Disorders and the Disrupted Gut Microbial Milieu

Mood Disorders and the Disrupted Gut Microbial Milieu

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Lower diversity of microbial populations in the human gut has been identified in individuals with major depressive disorder.

Cognition in Depression: A Critical Domain for Health Outcomes, Measurement, and Treatment

Cognition in Depression: A Critical Domain for Health Outcomes, Measurement, and Treatment

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Dr. Roger McIntyre suggests that the clinical relevance of cognitive dysfunction for any individual patient can only be adjudicated on a case-by-case basis.

Whole Body Hyperthermia: The Future of Depression Treatment?

Whole Body Hyperthermia: The Future of Depression Treatment?

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Researchers investigated the lasting effects of whole body hyperthermia (WBH) in the first randomized, double-blind, [placebo]-controlled study of WBH for the treatment of MDD.

Does Impaired Cognition Precede Depression?

Does Impaired Cognition Precede Depression?

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Dysfunction across several cognitive domains is often concomitant with depression.

"Frequent Flyers" in Emergency Department More Likely to Have Depression

"Frequent Flyers" in Emergency Department More Likely to Have Depression

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"Detecting depression in the emergency department is of utmost importance," Dr. Brickman and colleagues wrote in their publication.

EEG Registry Reduces Trial-and-Error Approach to Depression Treatment

EEG Registry Reduces Trial-and-Error Approach to Depression Treatment

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The registry contains more than 10,000 EEGs and 38,000 pharmacological outcomes, and is accessible to clinicians worldwide.

Brain-derived Neurotrophic Factor and its Precursor proBDNF as Diagnostic Biomarkers for Mood Disorders

Brain-derived Neurotrophic Factor and its Precursor proBDNF as Diagnostic Biomarkers for Mood Disorders

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mBDNF/proBDNF ratio could potentially serve as a novel biomarker for mood disorders.

The Neuroanatomy of, and Cognitive Deficits in, Depression: A Brief Overview

The Neuroanatomy of, and Cognitive Deficits in, Depression: A Brief Overview

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Atrophy of numerous structures within the central nervous system has been observed in persons suffering from depression.

Late-onset Depression Associated with Elevated Dementia Risk

Late-onset Depression Associated with Elevated Dementia Risk

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Dementia risk was particularly elevated in patients with depression who had higher scores on cognitive tests at baseline.

Investigating Risk Factors for Postpartum Depression

Investigating Risk Factors for Postpartum Depression

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The First Baby Study at Penn State College of Medicine includes more than 3 000 women in Pennsylvania having their first baby.

Associations Between Comorbid Cigarette, Alcohol, and Marijuana Use and Psychopathology

Associations Between Comorbid Cigarette, Alcohol, and Marijuana Use and Psychopathology

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Understanding distinct patterns of comorbid substance use may be more relevant to prevention and treatment than focusing on one individual substance.

Cognitive Function in Depression: The Role of Melancholic Features

Cognitive Function in Depression: The Role of Melancholic Features

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Individuals diagnosed with melancholic major depressive disorder presented with more severe symptoms of depression compared with persons with non-melancholic depression.

ACC Activation to Reward Predicts Response to Psychotherapy for MDD

ACC Activation to Reward Predicts Response to Psychotherapy for MDD

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Sustained anterior cingulate cortex activation during rewarding events predicted better treatment response to Behavioral Activation Treatment for Depression.

Meta-Analysis: Depression Common in Patients Discharged From ICU

Meta-Analysis: Depression Common in Patients Discharged From ICU

Risk highest among patients with psych symptoms pre-ICU/psych distress symptoms while in ICU

Psychosocial and Demographic Predictors of Depression Among Individuals With Bipolar Disorder and Schizophrenia

Psychosocial and Demographic Predictors of Depression Among Individuals With Bipolar Disorder and Schizophrenia

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Bipolar disorder and schizophrenia are characterized by significant genetic overlap, as well as significant clinical presentation overlap.

Intergenerational Transmission of Risk for Depression

Intergenerational Transmission of Risk for Depression

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Grandchildren with both a depressed parent and depressed grandparent were at highest risk for MDD.

Optimal SF-36 Threshold to Screen for MDD, GAD in RA

Optimal SF-36 Threshold to Screen for MDD, GAD in RA

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An analysis of the SF-36 health survey found that the survey can accurately determine the presence of psychological disorders in patients with RA, and suggests that a threshold of ≤38 on the mental component summary score may be optimal to screen for these disorders.

Neural Correlates of Emotion Regulation in Adolescence Following Childhood Adversity

Neural Correlates of Emotion Regulation in Adolescence Following Childhood Adversity

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Childhood is a critical developmental period in the brain's response to traumatic stress such as family adversity.

Augmentation With Antidepressants in Schizophrenia Treatment Appears Safe and Efficacious

Augmentation With Antidepressants in Schizophrenia Treatment Appears Safe and Efficacious

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In terms of depressive and negative symptoms, in the present meta-analysis, researchers estimate that 1 in 9 patients with schizophrenia will improve with add-on antidepressants.

Identifying Depression: How Accurate is the PHQ-2?

Identifying Depression: How Accurate is the PHQ-2?

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The accuracy of the PHQ-2 in identifying major depression is lower than originally thought.

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