Depressive Disorders

Mental Health Problems in Adolescents With HIV: Overview & Expert Interview

Mental Health Problems in Adolescents With HIV: Overview & Expert Interview

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Adolescents infected with HIV have a greater risk for psychiatric hospitalizations compared with those not infected with HIV.

High Risk for Anxiety, Depression, and Stress Observed Among Single Mothers

High Risk for Anxiety, Depression, and Stress Observed Among Single Mothers

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This research promotes the use of more rigorous screening efforts for mental illness among single mothers.

Retirement Associated With Increased Risk for Depressive Symptoms

Retirement Associated With Increased Risk for Depressive Symptoms

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Employment status displayed a lagged effect on depression, with retirement preceding higher levels of depression 2 years after initial retirement status report.

Correctional Psychiatry: Challenges and Rewards

Correctional Psychiatry: Challenges and Rewards

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Approximately 15% of incarcerated people have serious mental illness, although that number can vary depending on the type of illness.

Poor Functional Outcomes Tied to Depressive Symptoms in Multiple Sclerosis

Poor Functional Outcomes Tied to Depressive Symptoms in Multiple Sclerosis

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Higher depressive symptoms in patients with multiple sclerosis was associated with lower employment and processing speed.

Cognitive Reserve Protects Against Depression in Multiple Sclerosis

Cognitive Reserve Protects Against Depression in Multiple Sclerosis

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Greater cognitive reserve may protect against depression in patients with multiple sclerosis.

Light Therapy Offers Nonpharmacologic Treatment for Perimenopausal Depression

Light Therapy Offers Nonpharmacologic Treatment for Perimenopausal Depression

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Light treatments successfully corrected abnormal timing of melatonin circadian rhythms in perimenopausal women with depression and improved mood and sleep within 2 weeks.

Depressive Symptoms Have Greater Negative Effect on MS Functional Outcomes Than Anxiety

Depressive Symptoms Have Greater Negative Effect on MS Functional Outcomes Than Anxiety

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The authors noted a potential for a complex and dynamic relationship between depression and functional outcomes in multiple sclerosis , with greater dysfunction possibly increasing levels of depression.

Pain, Depression, and Opioid Misuse May Be Associated With Drug Overdoses

Pain, Depression, and Opioid Misuse May Be Associated With Drug Overdoses

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Pain conditions may largely be underrecognized contributors to the overdose epidemic.

Antidepressant Effects of Ketamine Appear to Require Opioid System Activation

Antidepressant Effects of Ketamine Appear to Require Opioid System Activation

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Researchers conducted a double-blind crossover study in adults with treatment-resistant depression to determine the involvement of the opioid system in ketamine's antidepressant effects.

Cost-Effective Telehealth Alternatives for Veterans With Depression

Cost-Effective Telehealth Alternatives for Veterans With Depression

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Researchers working with a population of veterans found that the healthcare utilization costs of telehealth services were significantly cheaper compared with in-person visits, with only a relatively small difference in quality of life.

Gestational Diabetes Associated With Increased Risk for Postpartum Depression

Gestational Diabetes Associated With Increased Risk for Postpartum Depression

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These findings suggest an increased risk for postpartum depressive symptoms in mothers with gestational diabetes, independent of depressive symptomatology during pregnancy.

Combination Cognitive Behavioral Therapy With Fluoxetine Effective for Adolescent Depression

Combination Cognitive Behavioral Therapy With Fluoxetine Effective for Adolescent Depression

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This research suggests that combination therapy not only produces greater proportional response in depression symptoms but that it is also effective in a broader range of individuals.

Selective Serotonin Reuptake Inhibitors May Increase Risk for Suboptimal Fetal Growth

Selective Serotonin Reuptake Inhibitors May Increase Risk for Suboptimal Fetal Growth

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Use of serotonin reuptake inhibitors for maternal depression may increase the risk for low birth weight in children.

Transdermal Nicotine Boosts Mood and Cognitive Function in Late-Life Depression

Transdermal Nicotine Boosts Mood and Cognitive Function in Late-Life Depression

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Results showed a significant change in depression severity with a mean MADRS reduction of 18.45 and a response rate of 86.7%.

Ketamine Infusions Reduce Suicidal Ideation in Depression: Characterizing Different Responses

Ketamine Infusions Reduce Suicidal Ideation in Depression: Characterizing Different Responses

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Researchers found 3 distinct subgroups of patients in relation to suicidal ideation and effects of ketamine, with one group's suicidal ideation completely eliminated and the other group's improvement independent of depressed mood.

Sex Differences in Comorbid Chronic Pain and Depression Examined

Sex Differences in Comorbid Chronic Pain and Depression Examined

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Chronic neuropathic pain has a large impact on quality of life and often causes or increases depressive symptoms for both men and women.

Psychotropic Drug Indications

Drug comparisons for mood disorders such as bipolar disorder, major depressive disorder, treatment resistant depression, premenstrual dysphoric disorder, and others.

White Matter Microstructure Variations Increase Risk for Depression in Adolescents

White Matter Microstructure Variations Increase Risk for Depression in Adolescents

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These adolescents may have delayed white matter maturation or early alterations in tracts connecting the anterior corpus callosum to the anterior cingulate cortex, which may carry a high risk for transition to depression.

Combinatorial Pharmacogenetics Useful in Treatment for Depression

Combinatorial Pharmacogenetics Useful in Treatment for Depression

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These data support the clinical use of combinatorial pharmacogenetics for patients with major depressive disorder.

Identifying Trajectory Classes of Postpartum Depressive Symptoms

Identifying Trajectory Classes of Postpartum Depressive Symptoms

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The high-risk class was associated with risk factors such as complications after birth, elevated depressive symptoms during pregnancy, and previous mental illness.

Guidelines for Managing Perimenopausal Depression Now Available

Guidelines for Managing Perimenopausal Depression Now Available

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The first-ever guidelines for the evaluation and treatment of perimenopausal depression have been published.

Esketamine Nasal Spray NDA Submitted to FDA for Treatment-Resistant Depression

Esketamine Nasal Spray NDA Submitted to FDA for Treatment-Resistant Depression

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The NDA includes five Phase 3 studies in patients with treatment-resistant depression: 3 short-term studies, 1 withdrawal maintenance of effect study, and 1 long-term safety study.

Improving Psychotherapy Dosing for Comorbid Depression and Personality Disorders

Improving Psychotherapy Dosing for Comorbid Depression and Personality Disorders

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Researchers are conducting a trial to determine whether 25 or 50 psychotherapy sessions in a year will be more effective at reducing symptoms of depression in patients with personality disorders.

Parental Religiosity May Lower Risk for Suicidal Ideation in Offspring

Parental Religiosity May Lower Risk for Suicidal Ideation in Offspring

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This study suggests that parental spirituality may affect offspring mental health, particularly regarding suicidal behaviors.

Lurasidone Effective for Treatment of Depression, Not Associated With Sexual Dysfunction

Lurasidone Effective for Treatment of Depression, Not Associated With Sexual Dysfunction

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These data suggest that lurasidone is effective in treating major depressive disorder with manic features without introducing sexual dysfunction.

Psilocybin Study Gets Green Light From FDA for Treatment-Resistant Depression

Psilocybin Study Gets Green Light From FDA for Treatment-Resistant Depression

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The trial will be a Phase 2b dose-ranging study (N=216) with patients from 12-15 research centers across Europe and North America.

Symptoms of Sleep Disorders Prevalent in Psychiatric Illnesses

Symptoms of Sleep Disorders Prevalent in Psychiatric Illnesses

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The authors argue that identifying and treating sleep disorders during early stages may have a positive impact on outcomes in psychiatric patients.

Reducing Off-Label Quetiapine Prescribing the Old-Fashioned Way: Snail Mail

Reducing Off-Label Quetiapine Prescribing the Old-Fashioned Way: Snail Mail

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Despite the associated risk for death and cognitive decline, "off-label" prescribing of antipsychotics in patients with dementia has increased.

Cortisol Levels May Contribute to Global Cognitive Decline in Elderly Adults With Depression

Cortisol Levels May Contribute to Global Cognitive Decline in Elderly Adults With Depression

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These data indicate that cortisol levels may contribute to the cognitive decline observed in elderly adults with late-life depression.

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