Depressive Disorder

Prenatal SSRI Exposure Associated With Fetal Neurodevelopmental Changes

Prenatal SSRI Exposure Associated With Fetal Neurodevelopmental Changes

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These data indicate a potential association between prenatal SSRI exposure and the development of the fetal amygdala-insula circuit, possibly via anomalous serotonin signaling.

Esketamine Evaluated in MDD Patients at Imminent Risk for Suicide

Esketamine Evaluated in MDD Patients at Imminent Risk for Suicide

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If approved, esketamine has the potential to be the first treatment for patients with major depressive disorder at imminent risk for suicide.

FDA to Review Opioid System Modulator for Major Depressive Disorder

FDA to Review Opioid System Modulator for Major Depressive Disorder

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ALKS 5461 consists of a fixed-dose combination of buprenorphine and samidorphan.

Clinical Outcomes Assessed for Major Depressive Disorder With Psychotic Features

Clinical Outcomes Assessed for Major Depressive Disorder With Psychotic Features

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Major depressive disorder with psychotic features had comparative long-term outcomes with schizophrenia, schizoaffective disorder, and bipolar disorder.

Mood Disorders Up for Children of Consanguineous Parents

Mood Disorders Up for Children of Consanguineous Parents

Children of first-cousin consanguineous parents have increased odds of mental health issues and needing antidepressant medications.

Adolescent Anxiety, Depression Risks Not Directly Associated With Perinatal HIV Status

Adolescent Anxiety, Depression Risks Not Directly Associated With Perinatal HIV Status

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Investigators assessed the prevalence and risk factors associated with symptoms of anxiety and depression in adolescents with HIV and those without infection but affected by HIV.

Antidepressant Types Linked to Different Adverse Outcomes in Adults With Depression

Antidepressant Types Linked to Different Adverse Outcomes in Adults With Depression

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Selective serotonin reuptake inhibitors and other antidepressants, such as tricyclic antidepressants, are associated with increased adverse outcomes in patients aged 20 to 64 years diagnosed with depression.

Stopping Exercise Found to Increase Depressive Symptoms

Stopping Exercise Found to Increase Depressive Symptoms

Ceasing regular exercise increases depressive symptoms, particularly in women.

Depression-Associated Stigma May Limit Access to Chronic Pain Care

Depression-Associated Stigma May Limit Access to Chronic Pain Care

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Individuals with chronic pain and comorbid depression may experience higher levels of stigma related to their conditions compared with patients with chronic pain alone.

ECT Does Not Increase the Risk for Dementia in Those With Affective Disorders

ECT Does Not Increase the Risk for Dementia in Those With Affective Disorders

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Findings from a cohort study suggest that ECT is not associated with increased risk for dementia, even in the elderly.

Untreated Depression Common in Women of Childbearing Age

Untreated Depression Common in Women of Childbearing Age

Many non-pregnant women of childbearing age are suffering from untreated depression.

Updated Guidelines for Identifying, Managing Depression in Adolescents

Updated Guidelines for Identifying, Managing Depression in Adolescents

Practice guidelines have been updated to assist primary care physicians in the screening and treatment of adolescent depression.

Emergency Mental Health Services During Hurricane Harvey: Challenges and Lessons

Emergency Mental Health Services During Hurricane Harvey: Challenges and Lessons

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Bipolar disorder (31.9%), depression (19.8%), schizophrenia (14.2%), and anxiety disorders (9.1%) were the most common mental health issues reported. Approximately 13% of evacuees with a mental health concern reported a history of post-traumatic stress disorder.

Early Menarche Linked to Antisocial Behavior, Depression That Persists Into Adulthood

Early Menarche Linked to Antisocial Behavior, Depression That Persists Into Adulthood

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These results indicated a persistence of depressive and antisocial symptoms and related behavioral patterns far beyond what has been demonstrated in prior research.

Effects of Depression, Alcohol Use on Retention in Antiretroviral Therapy

Effects of Depression, Alcohol Use on Retention in Antiretroviral Therapy

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Alcohol use disorder and depression were both associated with higher disengagement from antiretroviral therapy for patients with HIV.

Third Trimester Maternal SSRI Exposure Linked to Depression, Anxiety in Offspring

Third Trimester Maternal SSRI Exposure Linked to Depression, Anxiety in Offspring

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The issue of whether and how prenatal SSRI exposure affects offspring has remained murky.

Dermatologists May Need Further Training in Identifying Depression

Dermatologists May Need Further Training in Identifying Depression

Fair to poor concordance was seen between dermatologist assessment and patient self-reporting.

Examining Anxious Depression: Differences in Course and Outcomes

Examining Anxious Depression: Differences in Course and Outcomes

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Variability in definitions of "anxious depression" in research impedes the ability to make clear comparisons.

Continuation of ECT Improves Quality of Life in Depressed Elderly

Continuation of ECT Improves Quality of Life in Depressed Elderly

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These findings show that electroconvulsive therapy is a medically appropriate choice for elderly adults with depression and is likely to produce sustained improvement.

Careful Assessment for Depression Required for Patients With IBD

Careful Assessment for Depression Required for Patients With IBD

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Single-question self-assessment is not a sufficient marker of identifying depression in people with IBD.

Concomitant SSRI, Oral Anticoagulants Increase Risk for Hemorrhage in Ischemic Stroke

Concomitant SSRI, Oral Anticoagulants Increase Risk for Hemorrhage in Ischemic Stroke

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The relationship between selective serotonin-reuptake inhibitor use and outcomes after ischemic stroke was examined.

Do Biologic Agents Lower Depression Risk in Psoriasis?

Do Biologic Agents Lower Depression Risk in Psoriasis?

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Treatment with biologic agents in psoriasis may reduce risk for depressive symptoms.

Depression Screening Tools Accurate in Post-Acute Coronary Syndrome

Depression Screening Tools Accurate in Post-Acute Coronary Syndrome

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Cognitive behavioral therapy combined with antidepressant medication modestly improves psychosocial outcomes.

Antidepressant Effectiveness for Depression in Schizophrenia

Antidepressant Effectiveness for Depression in Schizophrenia

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Antidepressants may effectively treat depression in patients with comorbid schizophrenia.

Effectiveness of Exercise in Decreasing Depressive Symptoms

Effectiveness of Exercise in Decreasing Depressive Symptoms

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Lifestyle factors including exercise may be a strategic target to decrease symptoms of depression.

Paternal Depression Linked to Risk for Depressive Symptoms in Adolescents

Paternal Depression Linked to Risk for Depressive Symptoms in Adolescents

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Researchers found a positive association between paternal and adolescent depressive symptoms.

Neuroactive Steroids May Be Therapeutic Targets for Depression and Anxiety

Neuroactive Steroids May Be Therapeutic Targets for Depression and Anxiety

Women at both ends of the weight spectrum have low serum allopregnanolone which can be linked to severe depression and anxiety.

Poor Treatment Response in Adolescent Depression Not Linked to Network Density

Poor Treatment Response in Adolescent Depression Not Linked to Network Density

Adolescents with depression do not have more densely connected networks.

Fluvoxamine Effective for Depression in Patients With Neurological Disorders

Fluvoxamine Effective for Depression in Patients With Neurological Disorders

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Fluvoxamine was effective for the treatment of depression in patients with neurological disorders and depression.

Monetary Incentives Improve Cessation in Mentally Ill Smokers

Monetary Incentives Improve Cessation in Mentally Ill Smokers

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Abstinence-contingent incentives improved smoking cessation outcomes among economically disadvantaged smokers with mental illness.

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