Dementia

Higher Blood Pressure at Midlife Increases Risk for Dementia

Higher Blood Pressure at Midlife Increases Risk for Dementia

The risk of dementia is increased in 50-year-olds with blood pressure ≥130 mm Hg, which is below the current threshold for hypertension.

Trials for Investigational Alzheimer Treatment Lanabecestat Discontinued

Trials for Investigational Alzheimer Treatment Lanabecestat Discontinued

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Phase 3 clinical trials for lanabecestat (Eli Lilly and AstraZeneca), an investigational Alzheimer disease treatment, are being discontinued for futility.

Lifetime Risks Temper Biomarker Tests for Alzheimer Disease Dementia

Lifetime Risks Temper Biomarker Tests for Alzheimer Disease Dementia

The lifetime risks of Alzheimer disease dementia vary considerably by age, gender, and the preclinical or clinical disease state.

Intellectual Activities in Later Life May Cut Dementia Risk

Intellectual Activities in Later Life May Cut Dementia Risk

There is a reduced risk for dementia for older Chinese adults actively participating in intellectual activities.

Greater Wealth Associated With Lower Risk for Dementia in English Study

Greater Wealth Associated With Lower Risk for Dementia in English Study

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Public health strategies for preventing dementia should target socioeconomic gaps to reduce health disparities and protect the disadvantaged.

Anxiety: Feature of Late-Onset Dementia or Modifiable Risk Factor?

Anxiety: Feature of Late-Onset Dementia or Modifiable Risk Factor?

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The researchers encouraged clinicians not to rely solely on medication to treat midlife anxiety, as benzodiazepines have been shown to increase mortality in certain groups; they pointed to talk therapy, meditation, and mindfulness-based interventions as possible considerations.

FNIH Launches Project to Identify Biosignatures of Neurodegenerative, Psychiatric Conditions

FNIH Launches Project to Identify Biosignatures of Neurodegenerative, Psychiatric Conditions

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Multimarker inflammatory biosignatures are expected to facilitate diagnosis and predict treatment outcomes for various central nervous system disorders, particularly Alzheimer disease and major depressive disorder.

Depression in Patients With Dementia May Increase Risk for Heart Disease

Depression in Patients With Dementia May Increase Risk for Heart Disease

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Clinicians should take depression into careful consideration when treating patients with Alzheimer dementia, as the two conditions combined may predispose patients to cardiovascular disease more than either condition alone.

Clinically Significant Anxiety Tied to Subsequent Dementia Risk

Clinically Significant Anxiety Tied to Subsequent Dementia Risk

These findings indicate that anxiety may be a risk factor for late-life dementia, excluding anxiety that is related to prodromal cognitive decline.

Mortality in Alzheimer Disease Not Strongly Associated With Antipsychotics

Mortality in Alzheimer Disease Not Strongly Associated With Antipsychotics

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These results suggest that antipsychotic exposure has no impact on relative mortality.

Anticholinergic Drug Use and Dementia: What's the Link?

Anticholinergic Drug Use and Dementia: What's the Link?

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The use of certain anticholinergic drugs may increase the risk of future dementia.

Hearing Aids May Mitigate Cognitive Decline, Memory Loss

Hearing Aids May Mitigate Cognitive Decline, Memory Loss

Using hearing aids may slow cognitive decline in later life.

Traumatic Brain Injury Associated With Increased Risk for Dementia

Traumatic Brain Injury Associated With Increased Risk for Dementia

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These data support the importance of TBI preventative measures and proper management strategies for subsequent dementia.

Association Between Psychosis and Development of Dementia in Older Men

Association Between Psychosis and Development of Dementia in Older Men

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The findings also suggested that more a more recent diagnosis of psychosis was a greater predictor of the development of dementia, as opposed to cases where patients had been living with psychotic disorder diagnoses for 10 years or more.

Phonemic Verbal Advantage in Mild Cognitive Impairment May Predict Risk for Alzheimer Disease

Phonemic Verbal Advantage in Mild Cognitive Impairment May Predict Risk for Alzheimer Disease

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Patients with a phonemic advantage at baseline should be followed more closely with a higher index of suspicion for progression to Alzheimer disease.

Dementia Care: Prescribing Trends of Antipsychotics, Mood Stabilizers, and Psychotropic Medications

Dementia Care: Prescribing Trends of Antipsychotics, Mood Stabilizers, and Psychotropic Medications

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Researchers concluded that the partnership did not accelerate the overall decline in antipsychotic medication use among study participants.

Healthy Lifestyle May Protect Against Dementia in Older Adult Carriers of APOE ε4

Healthy Lifestyle May Protect Against Dementia in Older Adult Carriers of APOE ε4

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A study was conducted to assess potential beneficial effects of a lifestyle intervention program on cognition in carriers of the APOE ε4 allele.

At-Home Program Aids Communication for Spouses With Dementia

At-Home Program Aids Communication for Spouses With Dementia

Spouses who are affected by dementia may benefit from an at-home dyadic, relationship-focused psychoeducational intervention.

Alcohol Use Disorder a Major Risk Factor in Dementia Onset

Alcohol Use Disorder a Major Risk Factor in Dementia Onset

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These findings support the recognition of alcohol use disorders as a major risk factor for all dementia types.

Predicting Progression From Normal Cognition to Mild Cognitive Impairment

Predicting Progression From Normal Cognition to Mild Cognitive Impairment

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There are a handful of biomarkers that offer potential value for predicting the risk for development of MCI symptoms from AD symptoms.

Positive Beliefs About Age May Protect Older Adults Against Dementia

Positive Beliefs About Age May Protect Older Adults Against Dementia

Positive beliefs about age may protect against dementia.

Intervention Improves Quality of Life, Agitation in Nursing Home Patients With Dementia

Intervention Improves Quality of Life, Agitation in Nursing Home Patients With Dementia

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Patients randomly assigned to the intervention experienced a statistically significant improvement in quality of life, agitation, and overall neuropsychiatric symptoms.

Symptoms of Apathy Linked With Risk for Dementia in Older Adults

Symptoms of Apathy Linked With Risk for Dementia in Older Adults

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Depressive symptoms and apathy were independently associated with incident dementia in community-dwelling older adults.

Probing the Link Between Mood Disorders and Lithium in Water Supplies

Probing the Link Between Mood Disorders and Lithium in Water Supplies

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Michael Thase, MD, comments on the potential for lithium in drinking water as a psychiatric prophylactic agent.

Increased Midlife Triglyceride Levels May Be a Modifiable Risk Factor for Alzheimer Disease

Increased Midlife Triglyceride Levels May Be a Modifiable Risk Factor for Alzheimer Disease

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Increased triglyceride levels at midlife are predictive of the presence of β-amyloid 20 years later in cognitively healthy individuals.

Risk for Dementia, Cognitive Decline May Be Linked to Age-Related Hearing Loss

Risk for Dementia, Cognitive Decline May Be Linked to Age-Related Hearing Loss

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There is a greater risk for cognitive decline and impairment in elderly patients who experience age-related hearing loss.

A Review of Interventions to Prevent Late-Life Dementia, Cognitive Decline

A Review of Interventions to Prevent Late-Life Dementia, Cognitive Decline

There is limited evidence for the benefits of different interventions to prevent late-life dementia.

Dementia Risk Not Associated With Proton Pump Inhibitor Use

Dementia Risk Not Associated With Proton Pump Inhibitor Use

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Dementia risk was associated with neither proton pump inhibitor exposure nor duration of use.

When and How to Initiate Driving Cessation Conversation for Dementia Patients

When and How to Initiate Driving Cessation Conversation for Dementia Patients

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40% of people with dementia are still driving.

Nonoptimal Serum Magnesium Levels Associated With Incident Dementia

Nonoptimal Serum Magnesium Levels Associated With Incident Dementia

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Low and high serum magnesium levels were shown to be associated with increased risk of all-cause dementia.

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