Antipsychotics May Increase Diabetes Risk in Adolescents
the Psychiatry Advisor take:
Children and adolescents who take antipsychotics are at increased risk for developing type 2 diabetes, researchers found.
René Ernst Nielsen, MD, PhD, of Aalborg University Hospital in Aalborg, Denmark, and colleagues examined more than 48,299 youths who were treated for psychiatric illness between 1999 and 2010. Overall, 7,253 were given antipsychotics, and 41,046 were not.
Among youths who were prescribed an antipsychotic medication, 0.72% (95% CI = 0.52% - 0.91%) developed type 2 diabetes, compared to 0.27% (95% CI = 0.22% - 0.32%) not prescribed an antipsychotic, the researchers reported in the Journal of the American Academy of Child & Adolescent Psychiatry.
Developing type 2 diabetes was also more likely if first psychiatric diagnosis was given at an older age (OR=1.19; 95% CI: 1.12-1.27, P< 0.001). In addition, shorter time to onset of diabetes was noted in female youths (OR=4.48; 95% CI: 2.90-6.91, P< 0.001).
“Strict indications for antipsychotic treatment and routine cardiometabolic monitoring are crucial,” the researchers concluded.
Taking Antipsychotics Heightens Kids' Diabetes Risk
Antipsychotics are associated with weight gain and diabetes. The risk and rate of diabetes in children and adolescents treated with antipsychotics is unclear.
A longitudinal register linkage case-control study of diabetes in all psychiatric patients aged <18 years in Denmark was performed from January 1999 through the end of June 2010.
Patients with and without antipsychotic exposure were compared regarding the occurrence of type 2 diabetes, defined as the prescription of oral antidiabetic medication. Regression analyses with type 2 diabetes as the dependent variable were conducted with sex, age, and diagnoses as covariates.
Sign Up for Free e-newsletters
Psychiatry Advisor Articles
- Age of Onset of Bipolar Disorder Linked With Substance Use Disorders
- Mind-Body Therapy and Psychiatry: Ancient Tools for Modern Practice
- Marijuana Use Associated With Poorer Depression Outcomes, Increased Suicidal Ideation
- Low Testosterone Linked With Social Anxiety in Boys With Klinefelter Syndrome
- Atypical Symptom Presentations in Pediatric OCD
- The Psychology of Hoarding Disorder: Approaches for Treatment
- Smartphone Applications for Depression and Anxiety: Are They Ready for Widespread Use?
- The Many Misconceptions of Catatonia: Treatment Is Often Successful With the Right Knowledge
- Digital Media Engagement Associated With ADHD Symptoms in Adolescents
- Strong Social Networks May Mitigate the Effects of Childhood Adversity
- Light Therapy Effective for Older Adults with Nonseasonal Depression
- AMA Adopts Policy on Augmented Intelligence
- Parental Belief in Religion Lowers Child Suicide Risk
- Appetitive Symptoms, Fluoxetine, and Light Therapy: Predicting Treatment Response for Nonseasonal Major Depression
- Bipolar Disorder Patients Benefit From Coping Strategies for Amplified Emotionality