Generic Name and Formulations:
Varenicline (as tartrate) 0.5mg, 1mg; tabs.
Indications for CHANTIX:
Smoking cessation aid.
Provide patients with counseling and educational support. Set a target "quit date". Begin therapy 1 week before target quit date. Alternatively, may begin therapy and then quit smoking between Days 8 and 35 of treatment. Take after eating with a glass of water. ≥18yrs: initially 0.5mg once daily on Days 1–3, then 0.5mg twice daily on Days 4–7, then 1mg twice daily thereafter. May reduce dose if intolerable nausea or other adverse effects occur. Treat for 12 weeks; may continue 12 more weeks if patient successfully stops smoking to further increase the likelihood of abstinence. Patients who are not able or willing to quit abruptly: consider a gradual approach; begin Chantix dosing and reduce smoking by 50% from baseline within the 1st four weeks, by an additional 50% in the next four weeks, and continue reducing with the goal of complete abstinence by 12 weeks; continue for a total of 24 weeks of treatment. If patient motivated to quit and did not succeed, encourage another attempt with Chantix once factors contributing to failed attempt have been addressed. Severe renal impairment: initially 0.5mg once daily; may titrate to max 0.5mg twice daily. ESRD with hemodialysis: max 0.5mg once daily if tolerated.
<18yrs: not established.
Monitor for neuropsychiatric adverse events (eg, behavioral changes, agitation, depression, suicidal ideation); evaluate and consider dose reduction, continue therapy under closer monitoring, or discontinuation if occur. Pre-existing psychiatric disorders. History of seizures or other factors that can lower seizure threshold. Cardiovascular disease; monitor for new or worsening signs/symptoms. Renal impairment. Elderly. Pregnancy. Nursing mothers: monitor infant.
Nicotinic receptor partial agonist.
May affect alcohol tolerance; reduce alcohol consumption until effects are known. Smoking cessation may affect metabolism of other drugs (eg, warfarin, theophylline, insulin). Increased adverse effects with nicotine replacement therapy.
Nausea, other GI effects (eg, constipation, flatulence, vomiting), sleep disturbance (eg, abnormal dreams, insomnia); nicotine withdrawal symptoms (due to smoking cessation), neuropsychiatric symptoms (may be serious), cardiovascular events; seizures, somnambulism, angioedema, hypersensitivity reactions, serious skin reactions (rare); discontinue if occurs.
Tabs—56; Starting 4-week card (0.5mg x 11 tabs + 1mg x 42 tabs)—1; Continuing 4-week card (1mg x 56 tabs)—1; Starting Month Box (0.5mg x 11 tabs + 1mg x 42 tabs)—1; Continuing Month Box (1mg x 56 tabs)—1
Sign Up for Free e-newsletters
Psychiatry Advisor Articles
- Rapid Cycling in Bipolar Disorder: Overview and Expert Perspectives
- First-Episode Drug-Naive Patients With Schizophrenia More Likely to Attempt Suicide
- Posttraumatic Stress Disorder Associated With Reduced Brain Volume
- Early Childhood Out-of-Home Placement Associated With Adverse Outcomes in Adulthood
- ADHD Medications Compared for Efficacy, Tolerability in Children and Adults
- The Psychology of Hoarding Disorder: Approaches for Treatment
- Mind-Body Therapy and Psychiatry: Ancient Tools for Modern Practice
- Smartphone Applications for Depression and Anxiety: Are They Ready for Widespread Use?
- The Many Misconceptions of Catatonia: Treatment Is Often Successful With the Right Knowledge
- Marijuana Use Associated With Poorer Depression Outcomes, Increased Suicidal Ideation
- Symptoms of Anxiety, Depression Differ Depending on Gender, Race, Ethnicity
- Examining Whether Adjunctive Glutamatergic Medication Further Eases OCD Symptoms
- FDA Permits Marketing of Brain Stimulation Device for OCD
- Antipsychotics Adversely Affect Adiposity and Insulin Sensitivity in Youths
- Know Before You Go: Practicing Medicine Abroad