Generic Name and Formulations:
Sugammadex 100mg/mL; soln for IV inj.
Merck & Co., Inc.
Indications for BRIDION:
To reverse neuromuscular blockade induced by rocuronium bromide and vecuronium bromide in adults undergoing surgery.
Give as single bolus inj over 10 secs. Rocuronium and vecuronium: 4mg/kg if spontaneous recovery of the twitch response has reached 1–2 post-tetanic counts (PTC) with no twitch responses to train-of-four (TOF) stimulation. 2mg/kg if spontaneous recovery has reached the reappearance of the second twitch in response to TOF stimulation. Rocuronium only: 16mg/kg if reversal needed soon (approx. 3mins) after given a single rocuronium 1.2mg/kg dose. Re-administration of neuromuscular blockers post-reversal: see full labeling.
≤17yrs: not established.
Do not use to reverse blockade induced by agents other than rocuronium or vecuronium. Should be administered by trained healthcare providers. Have treatment for anaphylaxis readily available. Maintain ventilation and patent airway; monitor until recovery. Monitor for hemodynamic changes and administer anticholinergic agents (eg, atropine) if significant bradycardia observed. Risk of neuromuscular blockade recurrence; see full labeling. Coagulopathies. Signs of light anesthesia. Severe renal impairment (CrCl <30mL/min), dialysis: not recommended. Hepatic impairment with coagulopathy or severe edema. Elderly. Pregnancy. Nursing mothers.
Modified gamma cyclodextrin.
Recovery could be delayed with concomitant toremifene. May antagonize progestogen; if hormonal contraceptive taken on the same day as Bridion, must use additional non-hormonal contraceptive or back-up method (eg, condom, spermicide) for next 7 days. Increased bleeding risk with anticoagulation therapy, thromboprophylaxis drugs other than heparin and LMWH. May interfere with progesterone assay. Physically incompatible with verapamil, ondansetron, ranitidine.
Vomiting, pain, nausea, hypotension, headache; hypersensitivity, marked bradycardia, increases in aPTT and PT/INR.
Single-dose vials (2mL, 5mL)—10
Sign Up for Free e-newsletters
Psychiatry Advisor Articles
- Age of Onset of Bipolar Disorder Linked With Substance Use Disorders
- Rapid Cycling in Bipolar Disorder: Overview and Expert Perspectives
- Low Testosterone Linked With Social Anxiety in Boys With Klinefelter Syndrome
- Posttraumatic Stress Disorder Associated With Reduced Brain Volume
- First-Episode Drug-Naive Patients With Schizophrenia More Likely to Attempt Suicide
- The Psychology of Hoarding Disorder: Approaches for Treatment
- Mind-Body Therapy and Psychiatry: Ancient Tools for Modern Practice
- Smartphone Applications for Depression and Anxiety: Are They Ready for Widespread Use?
- The Many Misconceptions of Catatonia: Treatment Is Often Successful With the Right Knowledge
- Marijuana Use Associated With Poorer Depression Outcomes, Increased Suicidal Ideation