Generic Name and Formulations:
Doxylamine succinate 20mg, pyridoxine HCl 20mg; ext-rel tabs.
Duchesnay USA, Inc.
Indications for BONJESTA:
Nausea and vomiting of pregnancy in women who do not respond to conservative management.
Limitations Of use:
Not studied in women with hyperemesis gravidarum.
Swallow whole. Take on empty stomach with water. ≥18yrs: Day 1: initially 1 tab at bedtime; continue same dose next day if symptoms adequately controlled. If symptoms persist on Day 2, increase to 1 tab in AM and 1 tab at bedtime daily. Max 2 tabs daily.
<18yrs: not established.
Concomitant MAOIs; may prolong and intensify anticholinergic effects.
Asthma. Increased intraocular pressure. Narrow angle glaucoma. Stenosing peptic ulcer. Pyloroduodenal obstruction. Urinary bladder-neck obstruction. Reevaluate as pregnancy progresses. Nursing mothers: not recommended.
Antihistamine + Vit. B6 analog.
See Contraindications. Concomitant alcohol, other CNS depressants (eg, hypnotic sedatives, tranquilizers): not recommended. Concomitant food may delay onset of action and reduce absorption. May cause false (+) urine test for methadone, opiates, PCP.
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