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BLOCADREN
CHF and arrhythmias
Hypertension
Migraine and headache
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Drug Name:

BLOCADREN Rx

Generic Name and Formulations:
Timolol maleate 5mg, 10mg+, 20mg+; tabs; +scored.

Company:
Merck & Co., Inc.

Therapeutic Use:

Indications for BLOCADREN:

In stabilized patients after MI, to reduce mortality and risk of reinfarction.

Adult:

10mg twice daily.

Children:

Not recommended.

Contraindications:

Asthma. Severe COPD. Sinus bradycardia. 2nd- or 3rd-degree AV block. Overt heart failure. Cardiogenic shock.

Warnings/Precautions:

CHF. Ischemic heart disease. Bronchospastic disease, COPD. Renal or hepatic dysfunction. Diabetes. Hyperthyroidism. Cerebrovascular insufficiency. Surgery. SLE. Avoid abrupt cessation. Pregnancy (Cat.C). Nursing mothers: not recommended.

Pharmacological Class:

Beta-blocker.

Interactions:

Hypotension, bradycardia with catecholamine-depleting drugs. May increase cardiac effects of calcium channel blockers, digitalis. May be potentiated by quinidine. Increased rebound hypertension with clonidine withdrawal. Antagonized by NSAIDs. Adjust antidiabetic medications. May interfere with glaucoma screening tests. May block epinephrine.

Adverse Reactions:

Cardiac failure, bronchospasm, asthenia, bradycardia, dizziness, arrhythmia, heart block, dyspnea, muscle weakness, cold extremities, decreased libido, chest pain, syncope, pruritus.

How Supplied:

Tabs—100

Indications for BLOCADREN:

Hypertension.

Adult:

Initially 10mg twice a day. Increase weekly if needed. Usual maintenance: 20–40mg/day; max 60mg/day in 2 divided doses.

Children:

Not recommended.

Contraindications:

Asthma. Severe COPD. Sinus bradycardia. 2nd- or 3rd-degree AV block. Overt heart failure. Cardiogenic shock.

Warnings/Precautions:

CHF. Ischemic heart disease. Bronchospastic disease, COPD. Renal or hepatic dysfunction. Diabetes. Hyperthyroidism. Cerebrovascular insufficiency. Surgery. SLE. Avoid abrupt cessation. Pregnancy (Cat.C). Nursing mothers: not recommended.

Pharmacological Class:

Noncardioselective beta-blocker.

Interactions:

Hypotension, bradycardia with catecholamine-depleting drugs. May increase cardiac effects of calcium channel blockers, digitalis. May be potentiated by quinidine. Increased rebound hypertension with clonidine withdrawal. Antagonized by NSAIDs. Adjust antidiabetic medications. May interfere with glaucoma screening tests. May block epinephrine.

Adverse Reactions:

Cardiac failure, bronchospasm, asthenia, bradycardia, dizziness, arrhythmia, heart block, dyspnea, muscle weakness, cold extremities, decreased libido, chest pain, syncope, pruritus.

How Supplied:

Tabs—100

Indications for BLOCADREN:

Migraine prophylaxis.

Adult:

Initially 10mg twice a day. Increase weekly if needed; max 30mg daily in 2 divided doses. Evaluate at 6–8 wks.

Children:

Not recommended.

Contraindications:

Asthma. Severe COPD. Sinus bradycardia. 2nd- or 3rd-degree AV block. Overt heart failure. Cardiogenic shock.

Warnings/Precautions:

CHF. Ischemic heart disease. Bronchospastic disease, COPD. Renal or hepatic dysfunction. Diabetes. Hyperthyroidism. Cerebrovascular insufficiency. Surgery. SLE. Avoid abrupt cessation. Pregnancy (Cat.C). Nursing mothers: not recommended.

Pharmacological Class:

Noncardioselective beta-blocker.

Interactions:

Hypotension, bradycardia with catecholamine-depleting drugs. May increase cardiac effects of calcium channel blockers, digitalis. May be potentiated by quinidine. Increased rebound hypertension with clonidine withdrawal. Antagonized by NSAIDs. Adjust antidiabetic medications. May interfere with glaucoma screening tests. May block epinephrine.

Adverse Reactions:

Cardiac failure, bronchospasm, asthenia, bradycardia, dizziness, arrhythmia, heart block, dyspnea, muscle weakness, cold extremities, depression, decreased libido, chest pain, syncope, pruritus.

How Supplied:

Tabs—100

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