Bipolar Disorders

Sodium Valproate May Lower Amygdala Volume in Pediatric Bipolar Disorder

Sodium Valproate May Lower Amygdala Volume in Pediatric Bipolar Disorder

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Studies conducted in animals and adults have indicated that sodium valproate may have neuroprotective and neurotrophic effects, but the effects of sodium valproate on brain structure in pediatric bipolar disorder are not known.

Distinct Characteristics in Children at Risk for Schizophrenia vs Bipolar Disorder

Distinct Characteristics in Children at Risk for Schizophrenia vs Bipolar Disorder

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The findings of this study contribute to the understanding of the neurodevelopmental cognitive vulnerability in middle childhood for the children of people with either schizophrenia or bipolar disorder.

Executive Function Impairment in Unipolar vs Bipolar Depression

Executive Function Impairment in Unipolar vs Bipolar Depression

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These results suggest that executive function impairments may be similar in patients with unipolar and bipolar depression.

Managing Comorbid Migraine and Mood Disorders: A Synergistic Approach

Managing Comorbid Migraine and Mood Disorders: A Synergistic Approach

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People with migraines and comorbid mood disorders often need treatments that address both conditions, as well as management of sleep, stress, and lifestyle issues.

Once-Monthly Aripiprazole Effective as Maintenance Treatment for Bipolar I Disorder

Once-Monthly Aripiprazole Effective as Maintenance Treatment for Bipolar I Disorder

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These data demonstrate the efficacy and safety of AOM 400 in long-term maintenance treatment of bipolar I disorder and support its broader use in the medical field.

Childhood Abuse Linked to Compromised White Matter Integrity in Bipolar Disorder

Childhood Abuse Linked to Compromised White Matter Integrity in Bipolar Disorder

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These findings are in line with previous research, which suggested that abuse and neglect in childhood have different effects on the brain.

Medication Adherence Predictors in Patients With Severe Psychiatric Disorders

Medication Adherence Predictors in Patients With Severe Psychiatric Disorders

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As antipsychotic medications are vital to the effective management of severe psychiatric disorders, investigators sought to examine reasons for medication nonadherence in patients with schizophrenia, bipolar disorders, and other psychotic disorders.

Abnormal Frontal Gyrus, Limbic Activity Observed During Attentional Activity in Pediatric Bipolar Disorder

Abnormal Frontal Gyrus, Limbic Activity Observed During Attentional Activity in Pediatric Bipolar Disorder

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These results may be helpful in elucidating the specific brain mechanisms of bipolar disorder during cognitive development.

Personality Disorders Related to Adverse Outcomes in Bipolar Disorder

Personality Disorders Related to Adverse Outcomes in Bipolar Disorder

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These data may lead to a more nuanced understanding of bipolar disorder and to a better definition of the effectiveness of interventions directed at treating both personality disorders and bipolar disorder.

Relationship Between Impulsivity, Sleep Changes in Adolescents With Bipolar Disorder

Relationship Between Impulsivity, Sleep Changes in Adolescents With Bipolar Disorder

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Sleep routines may be an important therapeutic target for adolescents with bipolar disorder.

Examining Treatment Modalities for Noninvasive Brain Stimulation for Adult Depression

Examining Treatment Modalities for Noninvasive Brain Stimulation for Adult Depression

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These data could be useful to clinicians and patients alike in selecting the proper treatment method.

HIV Viral Suppression Rates in Psychiatric Inpatients With Comorbid Substance Use Disorders

HIV Viral Suppression Rates in Psychiatric Inpatients With Comorbid Substance Use Disorders

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A substantial proportion of these individuals diagnosed with HIV, psychiatric disorders, and substance use disorders are out of care and urgently require intervention.

Family History of Psychiatric Disorders an Important Predictor of Postpartum Psychiatric Illness

Family History of Psychiatric Disorders an Important Predictor of Postpartum Psychiatric Illness

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When assessing risk for postpartum episodes, clinicians should inquire about family history of psychiatric disorders broadly and not limit discussion to postpartum psychiatric disorders or psychiatric disorders in female relatives.

Childhood-Onset Bipolar Disorder Associated With Impaired Family Functioning

Childhood-Onset Bipolar Disorder Associated With Impaired Family Functioning

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Further investigation into the family-based mechanisms of childhood-onset bipolar disorder may assist in the development of future targeted, effective therapies.

Valproate Use in Women Who Could Become Pregnant: The Argument for Informed Consent

Valproate Use in Women Who Could Become Pregnant: The Argument for Informed Consent

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There is currently no international agreement on the appropriate regulation of valproate in people who may become pregnant.

Circadian Rhythm Disruptions Associated With Mood Disorders, Adverse Quality of Life

Circadian Rhythm Disruptions Associated With Mood Disorders, Adverse Quality of Life

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This study had a sample size large enough to assess the effect of circadian disruption on mental health disorders, and was the first to objectively measure patterns of rest and activity (using accelerometers).

Smartphone-Based Monitoring for Bipolar Depression, Mania Symptoms: Results From MONARCA II Trial

Smartphone-Based Monitoring for Bipolar Depression, Mania Symptoms: Results From MONARCA II Trial

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The primary outcomes assessed were the differences in clinically assessed depressive and manic symptoms, as well as the rate of depressive and manic episodes.

Neurocognitive Profile in Comorbid OCD and Bipolar Disorder

Neurocognitive Profile in Comorbid OCD and Bipolar Disorder

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Investigators compared set-shifting, decision making, and central coherence in patients with bipolar disorder, OCD, and comorbid bipolar disorder with OCD.

Social Cognition May Moderate Neurocognition, Community Functioning in Bipolar Disorder

Social Cognition May Moderate Neurocognition, Community Functioning in Bipolar Disorder

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These findings indicate a significant modulative effect of social cognition on neurocognition and community functioning in bipolar disorder and thus may be relevant in titrating treatment in patients with varying social cognition levels.

Psychiatric Comorbidities Increase Neurologic Disability in Multiple Sclerosis

Psychiatric Comorbidities Increase Neurologic Disability in Multiple Sclerosis

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Patients with MS and comorbid psychiatric conditions have increased severity of subsequent neurological disability.

Personality Functioning Associated With Global Functioning in Bipolar Disorder I

Personality Functioning Associated With Global Functioning in Bipolar Disorder I

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These results highlight the potential utility of incorporating personality functioning assessments into bipolar disorder I treatment plans to fully restore global functioning during remission.

GDF-15 Levels: Examining Premature Aging in Bipolar Disorder

GDF-15 Levels: Examining Premature Aging in Bipolar Disorder

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Researchers noted that therapeutic interventions focused on GDF-15 levels may decrease mortality risk and increase longevity in patients with bipolar disorder.

Family-Focused Intervention Effective for Caregivers of Patients With Bipolar Disorder

Family-Focused Intervention Effective for Caregivers of Patients With Bipolar Disorder

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Patients associated with caregivers who received family-focused treatment also demonstrated a significant decrease in depressive symptoms compared with patients associated with caregivers in the control group.

Incidence of Psychiatric Disorders in Rheumatoid Arthritis

Incidence of Psychiatric Disorders in Rheumatoid Arthritis

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The incidence and prevalence of psychiatric disorders such as depression, anxiety, and bipolar disorder are higher in the rheumatoid arthritis population.

Examining Rates of Conversion From Unipolar Depression to Bipolar Disorder

Examining Rates of Conversion From Unipolar Depression to Bipolar Disorder

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Making mental health predictions based on clinical presentation has major limitations.

Bipolar Disorder Symptoms Lessened by Cognitive-Behavioral Therapy

Bipolar Disorder Symptoms Lessened by Cognitive-Behavioral Therapy

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CBT is effective in patients with bipolar disorder in decreasing the relapse rate and improving symptoms of depression and mania severity.

Does Methylphenidate Lead to Treatment-Emergent Mania?

Does Methylphenidate Lead to Treatment-Emergent Mania?

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Patients with comorbid bipolar disorder and ADHD may benefit from methylphenidate treatment, if it can be done without incurring the risk of mania.

Searching for Novel Endophenotypic Markers for Bipolar Disorder

Searching for Novel Endophenotypic Markers for Bipolar Disorder

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Intra-subject variability in reaction time (ISVRT) is viewed as a promising behavioral endophenotype for bipolar disorder.

Brain-derived Neurotrophic Factor and its Precursor proBDNF as Diagnostic Biomarkers for Mood Disorders

Brain-derived Neurotrophic Factor and its Precursor proBDNF as Diagnostic Biomarkers for Mood Disorders

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mBDNF/proBDNF ratio could potentially serve as a novel biomarker for mood disorders.

6-minute Walk Test Offers Insight Into Global Functioning Among Patients With Bipolar Disorder

6-minute Walk Test Offers Insight Into Global Functioning Among Patients With Bipolar Disorder

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Until now, assessment of aerobic exercise capacity included expensive and time-consuming laboratory tests that do not necessarily accurately reflect patients' day-to-day physical functioning.

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