Bipolar Disorders

Inflammation Associated With Gray Matter, Hippocampal Volume Reduction in Older Adults With Bipolar Disorder

Inflammation Associated With Gray Matter, Hippocampal Volume Reduction in Older Adults With Bipolar Disorder

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Inflammation appears to be associated with reductions in hippocampal and gray matter volumes in older patients with bipolar I disorder.

Mood Stabilizers Associated With Increased Risk for Stroke in Bipolar Disorder

Mood Stabilizers Associated With Increased Risk for Stroke in Bipolar Disorder

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Exposure to carbamazepine was associated with the highest risk for stroke, particularly ischemic stroke.

Customized Adherence Enhancement Intervention Improves Adherence Rates in Bipolar Disorder

Customized Adherence Enhancement Intervention Improves Adherence Rates in Bipolar Disorder

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Customized adherence enhancement may be most effective if implemented in individuals early in the course of bipolar disorder.

Education, Inflammation Predict Cognitive Performance in Bipolar Disorder

Education, Inflammation Predict Cognitive Performance in Bipolar Disorder

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Researchers set out to examine how bipolar disorder affects cognitive performance across a variety of clinical parameters.

High-Activity Temperaments Appear to Be Protective of Major Mood Episodes in Offspring at High Genetic Risk

High-Activity Temperaments Appear to Be Protective of Major Mood Episodes in Offspring at High Genetic Risk

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After a major depressive episode, sociability, activity, and self-esteem measures decreased, while emotionality and shyness scores increased.

Once-Monthly Aripiprazole as Maintenance Treatment for Bipolar I Disorder

Once-Monthly Aripiprazole as Maintenance Treatment for Bipolar I Disorder

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Treatment with 400 mg once-monthly injectable aripiprazole demonstrates efficacy in preventing recurrence of mood episodes in patients with bipolar I.

Mortality Rate for Bipolar Disorder Has Increased in Denmark Since the 1990s

Mortality Rate for Bipolar Disorder Has Increased in Denmark Since the 1990s

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Younger individuals may be more at risk for death by suicide, and in older patients, elevated levels of metabolic syndrome may lead to higher rates of death from heart disease.

Manic Episode Inpatient Admissions Appear to Peak During Summer

Manic Episode Inpatient Admissions Appear to Peak During Summer

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For manic episodes, admissions for men peaked in June, and in September for women.

Psychotropic Medications May Improve Pregnancy Outcomes in Bipolar Disorder

Psychotropic Medications May Improve Pregnancy Outcomes in Bipolar Disorder

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Reduced head circumference in the offspring of women with untreated bipolar disorder appeared to be related to sociodemographic characteristics.

Suicide Attempts Associated With Sleep and Circadian Rhythm Disturbances in Bipolar Disorder

Suicide Attempts Associated With Sleep and Circadian Rhythm Disturbances in Bipolar Disorder

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All patients with bipolar disorder had more circadian rhythm and sleep disturbances than healthy control patients.

Early Risk Factors for Bipolar Disorder Found in Offspring of BD Parents

Early Risk Factors for Bipolar Disorder Found in Offspring of BD Parents

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The most robust predictive risk factor for BD is a confirmed history of the illness in a first-degree relative, which is associated with an 8-fold to 10-fold lifetime risk for BD and a 2-fold to 3-fold lifetime risk for depressive disorder vs the general population.

Link Identified Between Cured Meat and Mania in Bipolar Disorder

Link Identified Between Cured Meat and Mania in Bipolar Disorder

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These results suggest that the nitrates in cured meat are driving the association between cured meat consumption and mania.

Lithium May Treat Children With Bipolar Disorder, but Pediatric Studies Are Lacking

Lithium May Treat Children With Bipolar Disorder, but Pediatric Studies Are Lacking

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Lithium appears to be a suitable treatment for pediatric bipolar disorder; however, dedicated research has been scarce.

Improvement in Guidelines for Monitoring Patients Receiving Lithium Essential

Improvement in Guidelines for Monitoring Patients Receiving Lithium Essential

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The quality of patient monitoring may improve if the clinical practice guidelines are improved, as many healthcare professionals use the guidelines in their monitoring of patients taking lithium.

Using DSM Criteria, Pediatric Bipolar Disorder Diagnoses Generally Remain Unchanged at Follow-Up

Using DSM Criteria, Pediatric Bipolar Disorder Diagnoses Generally Remain Unchanged at Follow-Up

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The authors of this study were interested in whether the criteria used to diagnose adults with bipolar disorder would be adequate for adolescents.

Illness Severity, Comorbid Clinical Features Affect Patient Capacity to Provide Informed Consent

Illness Severity, Comorbid Clinical Features Affect Patient Capacity to Provide Informed Consent

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Patients unable to give informed consent displayed insufficient understanding of the study risks and benefits and the difference between research and individualized care.

Coping Flexibility Predictive of Post-Event Mood State in Bipolar Disorder

Coping Flexibility Predictive of Post-Event Mood State in Bipolar Disorder

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This research suggests that coping flexibility and perceived controllability are crucial to the mood states of patients with bipolar disorder following Behavioral Approach System-activating stimuli.

FDA to Review Vraylar sNDA for Treatment of Bipolar Depression

FDA to Review Vraylar sNDA for Treatment of Bipolar Depression

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The FDA has accepted the supplemental New Drug Application for Vraylar as a treatment for depressive episodes associated with bipolar I disorder in adults.

Aggression in Bipolar I Disorder and Psychosis Associated With Suicidal Ideation, Alcohol Abuse

Aggression in Bipolar I Disorder and Psychosis Associated With Suicidal Ideation, Alcohol Abuse

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Management of alcohol abuse, suicidal ideation or behavior, and manic symptoms may reduce aggression among patients with bipolar disorder with psychotic features.

Assortative Mating Among Bipolar Patients in the United States Increases Risk for Illness in Offspring

Assortative Mating Among Bipolar Patients in the United States Increases Risk for Illness in Offspring

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The presence of unipolar depression in the spouse of someone with bipolar depression was associated with unipolar depression in their offspring, who had a 41.5% risk for developing that disorder.

Panel Recommends Earlier Body Weight Monitoring in Use of Mood Stabilizers

Panel Recommends Earlier Body Weight Monitoring in Use of Mood Stabilizers

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Mood stabilizers are useful for long-term management of bipolar disorder, but weight change can create an emotional burden for some patients, as well as heighten the risk for metabolic dysregulation.

Text Message Reminders Improve Medication Adherence in Bipolar I Disorder

Text Message Reminders Improve Medication Adherence in Bipolar I Disorder

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Researchers emphasize the cost-effectiveness of text message reminders in prompting individuals with bipolar I disorder to adhere to medication treatments.

Pilot Study Investigates Lithium vs Quetiapine for Bipolar Spectrum Disorder

Pilot Study Investigates Lithium vs Quetiapine for Bipolar Spectrum Disorder

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This pilot study demonstrates the potential efficacy and safety of lithium as a treatment option for bipolar disorder.

Polygenic Risk Scores Could Aid in Identifying Bipolar Disorder, Schizophrenia

Polygenic Risk Scores Could Aid in Identifying Bipolar Disorder, Schizophrenia

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While polygenic risk scores are not yet ready for clinical use, researchers found that patients with psychosis had significant increases in schizophrenia and bipolar polygenic risk scores.

Smartphone-Based Psychoeducational Programs May Be Effective for Bipolar Disorder Management

Smartphone-Based Psychoeducational Programs May Be Effective for Bipolar Disorder Management

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This research supports the efficacy of smartphone-based educational programs in the management of bipolar disorder.

Lithium Monotherapy Effective in Treating Bipolar Disorder in Children

Lithium Monotherapy Effective in Treating Bipolar Disorder in Children

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In terms of efficacy, 3 randomized controlled trials demonstrated that treatment with lithium monotherapy improved overall functioning and symptoms of mania or mixed mania in children and adolescents with bipolar illness.

Circadian Clock Genes Associated With Alcohol Dependence in Men

Circadian Clock Genes Associated With Alcohol Dependence in Men

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Researchers confirmed the existence of a direct link between clock genes and 2 comorbid diseases, as well as the genetic predisposition for alcohol abuse.

Childhood Trauma Associated With Impulsivity in Bipolar Disorder

Childhood Trauma Associated With Impulsivity in Bipolar Disorder

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Patients with bipolar disorder most often reported emotional abuse, emotional neglect, and physical neglect.

Lithium Efficacy, Safety Examined in Children, Adolescents With Bipolar Disorder

Lithium Efficacy, Safety Examined in Children, Adolescents With Bipolar Disorder

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With regard to safety, treatment with lithium in this patient population was considered "generally safe, at least in the short term."

Reducing Off-Label Quetiapine Prescribing the Old-Fashioned Way: Snail Mail

Reducing Off-Label Quetiapine Prescribing the Old-Fashioned Way: Snail Mail

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Despite the associated risk for death and cognitive decline, "off-label" prescribing of antipsychotics in patients with dementia has increased.

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