Inflammation Associated With Gray Matter, Hippocampal Volume Reduction in Older Adults With Bipolar DisorderNovember 07, 2018
Inflammation appears to be associated with reductions in hippocampal and gray matter volumes in older patients with bipolar I disorder.
Exposure to carbamazepine was associated with the highest risk for stroke, particularly ischemic stroke.
Customized adherence enhancement may be most effective if implemented in individuals early in the course of bipolar disorder.
Researchers set out to examine how bipolar disorder affects cognitive performance across a variety of clinical parameters.
High-Activity Temperaments Appear to Be Protective of Major Mood Episodes in Offspring at High Genetic RiskNovember 01, 2018
After a major depressive episode, sociability, activity, and self-esteem measures decreased, while emotionality and shyness scores increased.
Treatment with 400 mg once-monthly injectable aripiprazole demonstrates efficacy in preventing recurrence of mood episodes in patients with bipolar I.
Younger individuals may be more at risk for death by suicide, and in older patients, elevated levels of metabolic syndrome may lead to higher rates of death from heart disease.
For manic episodes, admissions for men peaked in June, and in September for women.
Reduced head circumference in the offspring of women with untreated bipolar disorder appeared to be related to sociodemographic characteristics.
All patients with bipolar disorder had more circadian rhythm and sleep disturbances than healthy control patients.
The most robust predictive risk factor for BD is a confirmed history of the illness in a first-degree relative, which is associated with an 8-fold to 10-fold lifetime risk for BD and a 2-fold to 3-fold lifetime risk for depressive disorder vs the general population.
These results suggest that the nitrates in cured meat are driving the association between cured meat consumption and mania.
Lithium appears to be a suitable treatment for pediatric bipolar disorder; however, dedicated research has been scarce.
The quality of patient monitoring may improve if the clinical practice guidelines are improved, as many healthcare professionals use the guidelines in their monitoring of patients taking lithium.
The authors of this study were interested in whether the criteria used to diagnose adults with bipolar disorder would be adequate for adolescents.
Patients unable to give informed consent displayed insufficient understanding of the study risks and benefits and the difference between research and individualized care.
This research suggests that coping flexibility and perceived controllability are crucial to the mood states of patients with bipolar disorder following Behavioral Approach System-activating stimuli.
The FDA has accepted the supplemental New Drug Application for Vraylar as a treatment for depressive episodes associated with bipolar I disorder in adults.
Management of alcohol abuse, suicidal ideation or behavior, and manic symptoms may reduce aggression among patients with bipolar disorder with psychotic features.
Assortative Mating Among Bipolar Patients in the United States Increases Risk for Illness in OffspringSeptember 25, 2018
The presence of unipolar depression in the spouse of someone with bipolar depression was associated with unipolar depression in their offspring, who had a 41.5% risk for developing that disorder.
Mood stabilizers are useful for long-term management of bipolar disorder, but weight change can create an emotional burden for some patients, as well as heighten the risk for metabolic dysregulation.
Researchers emphasize the cost-effectiveness of text message reminders in prompting individuals with bipolar I disorder to adhere to medication treatments.
This pilot study demonstrates the potential efficacy and safety of lithium as a treatment option for bipolar disorder.
While polygenic risk scores are not yet ready for clinical use, researchers found that patients with psychosis had significant increases in schizophrenia and bipolar polygenic risk scores.
This research supports the efficacy of smartphone-based educational programs in the management of bipolar disorder.
In terms of efficacy, 3 randomized controlled trials demonstrated that treatment with lithium monotherapy improved overall functioning and symptoms of mania or mixed mania in children and adolescents with bipolar illness.
Researchers confirmed the existence of a direct link between clock genes and 2 comorbid diseases, as well as the genetic predisposition for alcohol abuse.
Patients with bipolar disorder most often reported emotional abuse, emotional neglect, and physical neglect.
With regard to safety, treatment with lithium in this patient population was considered "generally safe, at least in the short term."
Despite the associated risk for death and cognitive decline, "off-label" prescribing of antipsychotics in patients with dementia has increased.
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