Further investigation into the family-based mechanisms of childhood-onset bipolar disorder may assist in the development of future targeted, effective therapies.
There is currently no international agreement on the appropriate regulation of valproate in people who may become pregnant.
This study had a sample size large enough to assess the effect of circadian disruption on mental health disorders, and was the first to objectively measure patterns of rest and activity (using accelerometers).
The primary outcomes assessed were the differences in clinically assessed depressive and manic symptoms, as well as the rate of depressive and manic episodes.
Investigators compared set-shifting, decision making, and central coherence in patients with bipolar disorder, OCD, and comorbid bipolar disorder with OCD.
These findings indicate a significant modulative effect of social cognition on neurocognition and community functioning in bipolar disorder and thus may be relevant in titrating treatment in patients with varying social cognition levels.
Patients with MS and comorbid psychiatric conditions have increased severity of subsequent neurological disability.
These results highlight the potential utility of incorporating personality functioning assessments into bipolar disorder I treatment plans to fully restore global functioning during remission.
Researchers noted that therapeutic interventions focused on GDF-15 levels may decrease mortality risk and increase longevity in patients with bipolar disorder.
Patients associated with caregivers who received family-focused treatment also demonstrated a significant decrease in depressive symptoms compared with patients associated with caregivers in the control group.
The incidence and prevalence of psychiatric disorders such as depression, anxiety, and bipolar disorder are higher in the rheumatoid arthritis population.
Making mental health predictions based on clinical presentation has major limitations.
CBT is effective in patients with bipolar disorder in decreasing the relapse rate and improving symptoms of depression and mania severity.
Patients with comorbid bipolar disorder and ADHD may benefit from methylphenidate treatment, if it can be done without incurring the risk of mania.
Intra-subject variability in reaction time (ISVRT) is viewed as a promising behavioral endophenotype for bipolar disorder.
Brain-derived Neurotrophic Factor and its Precursor proBDNF as Diagnostic Biomarkers for Mood DisordersSeptember 12, 2016
mBDNF/proBDNF ratio could potentially serve as a novel biomarker for mood disorders.
Until now, assessment of aerobic exercise capacity included expensive and time-consuming laboratory tests that do not necessarily accurately reflect patients' day-to-day physical functioning.
Irritability in Recovered Bipolar Disorder Patients Linked to Greater Morbidity, Depression RecurrenceAugust 22, 2016
Delayed depressive recovery occurred more in depressed patients with current irritability.
Direct comparison of white matter tracts between individuals with schizophrenia or bipolar disorder has not been performed to date.
Psychosocial and Demographic Predictors of Depression Among Individuals With Bipolar Disorder and SchizophreniaAugust 15, 2016
Bipolar disorder and schizophrenia are characterized by significant genetic overlap, as well as significant clinical presentation overlap.
The researchers quantified the transcript levels of GAD67, parvalbumin, somastatin, and Lhx6 in the prefrontal cortex.
New findings underline the potential importance of signaling pathways in the striatum for understanding bipolar disorder pathophysiology.
Exposure to Stressful Triggers Increases Risk for Violent Criminality Irrespective of Psychiatric ConditionJuly 13, 2016
The largest 7-day absolute risk of criminal violence was observed after exposure to violence in patients diagnosed with schizophrenia, bipolar disorder, as well as in unaffected individuals.
Bipolar disorder (BD) is typically characterized by recurrent episodes of mania and depression, but the connection between BD and anxiety needs to be considered.
Neuroimaging studies have shown several neurophysiological substrates for depression: An overview by Theodore Henderson, MD, PhD.
Nicotine-dependent smokers who began smoking in the 1980s were more likely than older smokers to have a psychiatric condition, such as bipolar disorder, antisocial personality disorder, or ADHD.
Chicken genes are grouped into much smaller linkage blocks than mammalian genomes are, allowing researchers to pinpoint genome regions associated with a trait, such as anxious behavior.
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Psychiatry Advisor Articles
- Childhood-Onset Bipolar Disorder Associated With Impaired Family Functioning
- Valproate Use in Women Who Could Become Pregnant: The Argument for Informed Consent
- Review Examines the Effectiveness of Antidepressants for Insomnia
- Ketamine-Induced Dissociative Symptoms Predict Antidepressant Response
- Hospitalization Rates in Schizophrenia—Lurasidone vs Quetiapine
- Video Games and Exercise as Alternative Therapies for ADHD
- How Parents Can Enhance Autism Treatment: Use of Intervention Strategies at Home
- Electroconvulsive Therapy Effective in Children With Autism
- Comorbid Autism Spectrum Disorder and OCD: Challenges in Diagnosis and Treatment
- The Cutting Edge of Schizophrenia Research: VR as Treatment for Psychosis
- New APA President Takes Office as the First African-American to Lead the Organization
- "MDMA-Assisted Psychotherapy Effective for Treating PTSD in Veterans, First Responders "
- Early Intervention Services Superior to Treatment as Usual for Early-Phase Psychosis
- Depressive Symptoms Predict Future Pain, Disability in Adolescent JIA
- Gender-Related Association Between Physical Activity, Psychological Status in T2D