Studies conducted in animals and adults have indicated that sodium valproate may have neuroprotective and neurotrophic effects, but the effects of sodium valproate on brain structure in pediatric bipolar disorder are not known.
The findings of this study contribute to the understanding of the neurodevelopmental cognitive vulnerability in middle childhood for the children of people with either schizophrenia or bipolar disorder.
These results suggest that executive function impairments may be similar in patients with unipolar and bipolar depression.
People with migraines and comorbid mood disorders often need treatments that address both conditions, as well as management of sleep, stress, and lifestyle issues.
These data demonstrate the efficacy and safety of AOM 400 in long-term maintenance treatment of bipolar I disorder and support its broader use in the medical field.
These findings are in line with previous research, which suggested that abuse and neglect in childhood have different effects on the brain.
As antipsychotic medications are vital to the effective management of severe psychiatric disorders, investigators sought to examine reasons for medication nonadherence in patients with schizophrenia, bipolar disorders, and other psychotic disorders.
Abnormal Frontal Gyrus, Limbic Activity Observed During Attentional Activity in Pediatric Bipolar DisorderJune 14, 2018
These results may be helpful in elucidating the specific brain mechanisms of bipolar disorder during cognitive development.
These data may lead to a more nuanced understanding of bipolar disorder and to a better definition of the effectiveness of interventions directed at treating both personality disorders and bipolar disorder.
Sleep routines may be an important therapeutic target for adolescents with bipolar disorder.
These data could be useful to clinicians and patients alike in selecting the proper treatment method.
A substantial proportion of these individuals diagnosed with HIV, psychiatric disorders, and substance use disorders are out of care and urgently require intervention.
When assessing risk for postpartum episodes, clinicians should inquire about family history of psychiatric disorders broadly and not limit discussion to postpartum psychiatric disorders or psychiatric disorders in female relatives.
Further investigation into the family-based mechanisms of childhood-onset bipolar disorder may assist in the development of future targeted, effective therapies.
There is currently no international agreement on the appropriate regulation of valproate in people who may become pregnant.
This study had a sample size large enough to assess the effect of circadian disruption on mental health disorders, and was the first to objectively measure patterns of rest and activity (using accelerometers).
The primary outcomes assessed were the differences in clinically assessed depressive and manic symptoms, as well as the rate of depressive and manic episodes.
Investigators compared set-shifting, decision making, and central coherence in patients with bipolar disorder, OCD, and comorbid bipolar disorder with OCD.
These findings indicate a significant modulative effect of social cognition on neurocognition and community functioning in bipolar disorder and thus may be relevant in titrating treatment in patients with varying social cognition levels.
Patients with MS and comorbid psychiatric conditions have increased severity of subsequent neurological disability.
These results highlight the potential utility of incorporating personality functioning assessments into bipolar disorder I treatment plans to fully restore global functioning during remission.
Researchers noted that therapeutic interventions focused on GDF-15 levels may decrease mortality risk and increase longevity in patients with bipolar disorder.
Patients associated with caregivers who received family-focused treatment also demonstrated a significant decrease in depressive symptoms compared with patients associated with caregivers in the control group.
The incidence and prevalence of psychiatric disorders such as depression, anxiety, and bipolar disorder are higher in the rheumatoid arthritis population.
Making mental health predictions based on clinical presentation has major limitations.
CBT is effective in patients with bipolar disorder in decreasing the relapse rate and improving symptoms of depression and mania severity.
Patients with comorbid bipolar disorder and ADHD may benefit from methylphenidate treatment, if it can be done without incurring the risk of mania.
Intra-subject variability in reaction time (ISVRT) is viewed as a promising behavioral endophenotype for bipolar disorder.
Brain-derived Neurotrophic Factor and its Precursor proBDNF as Diagnostic Biomarkers for Mood DisordersSeptember 12, 2016
mBDNF/proBDNF ratio could potentially serve as a novel biomarker for mood disorders.
Until now, assessment of aerobic exercise capacity included expensive and time-consuming laboratory tests that do not necessarily accurately reflect patients' day-to-day physical functioning.
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Psychiatry Advisor Articles
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- Remission of Treatment-Resistant Depression in Veterans Depends on Close Clinical Observation
- Medical Clearance of Psych Patients in the ED: Consensus Recommendations
- From Abused Child to Serial Killer: Investigating Nature vs Nurture in Methods of Murder
- Managing Comorbid Migraine and Mood Disorders: A Synergistic Approach
- Dialectical Behavior Therapy Effective in Reducing Suicide Attempts, Self-Harm in Adolescents
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- When Physicians Become Patients: Challenges in Seeking Health Care
- Long-Acting Injectables Effective in Patients With Comorbid Psychosis, Substance Use Disorder
- Strong Social Networks May Mitigate the Effects of Childhood Adversity
- Electroconvulsive Therapy Improves Global Cognition in Bipolar Disorder
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