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AZACTAM
Bacterial infections
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Drug Name:

AZACTAM Rx

Generic Name and Formulations:
Aztreonam 1g, 2g; for IM or IV inj after reconstitution; sodium-free.

Company:
Bristol-Myers Squibb

Therapeutic Use:

Indications for AZACTAM:

Susceptible bacterial infections, including septicemia, lower respiratory tract, complicated or uncomplicated urinary tract, skin and skin structure, gynecologic, intraabdominal. Surgical adjunct.

Adult:

UTI: 500mg–1g every 8–12hrs. Other systemic infections: moderately severe: 1–2g every 8–12hrs; severe: 2g every 6–8hrs. All: max 8g/day. Max 1g/dose by IM. Renal impairment (CrCl 10–30mL/min): ½ of dose after loading dose; CrCl <10mL/min: see full labeling.

Children:

<9mos: not established. Not for septicemia or certain skin and skin structure infections; see full labeling. 9mos–16yrs (normal renal function only): urinary tract, lower respiratory tract, intraabdominal, gynecologic infections: mild-to-moderate: 30mg/kg IV every 8hrs; moderate-to-severe: 30mg/kg IV every 6–8hrs; max 120mg/kg/day. May need higher dose in patients with cystic fibrosis.

Warnings/Precautions:

Penicillin, cephalosporin, carbapenem, or other allergy. Renal or hepatic impairment; monitor during therapy. Elderly. Pregnancy (Cat.B). Nursing mothers; consider temporary formula feedings.

Pharmacological Class:

Monobactam.

Interactions:

May potentiate nephrotoxicity of concomitant aminoglycosides (esp. at high doses or prolonged use); monitor renal function. Avoid concomitant β-lactamase-inducing drugs (eg, cefoxitin, imipenem).

Adverse Reactions:

Local reactions (eg, phlebitis, discomfort), GI upset, rash, anaphylaxis, blood dyscrasias, elevated liver enzymes or serum creatinine; C. difficile-associated diarrhea, superinfection; rare: toxic epidermal necrolysis.

How Supplied:

Single-dose vials (15mL)—10; GALAXY containers (50mL)—24

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