The investigators sought to evaluate the effect of 50 mg or 100 mg of desvenlafaxine vs placebo on symptom cluster scores in patients with MDD, as well as the association between early improvement in symptom clusters and symptomatic or functional remission at 8 weeks.
The investigators sought to examine the importance of depression severity as a predictor of ECT use, as well as the risk for mortality, rehospitalization, and suicidal behavior, in a nationwide sample of patients with a first-time hospital diagnosis of major depression.
Investigators sought to identify neurobiological and psychological predictors for risk for psychosis.
Researchers suggest that childhood trauma exposure exerts illness-specific effects on hippocampal structures in patients who are women with first-episode schizophrenia.
In a small Chinese cohort, investigators found that insular functional dysconnectivity within the sensory cortex may be a system-level neural substrate that precedes the onset of psychosis.
From a small cohort in China, researchers found data that showed in patients with early-stage schizophrenia, peripheral multisystemic and central nervous system abnormalities may interact through the choroid plexus.
Future advancements in delivery technologies of antipsychotics and their evaluation in clinical trials could help increase the number of available antipsychotic formulations for the treatment of psychiatric disorders, including transdermal antipsychotic drug formulations for patients with schizophrenia.
Real-world data suggest that, before determining that a patient has clozapine-resistant schizophrenia, combination antipsychotic therapy should be sought.
In Brazil, researchers assessed blood serum identified with the use of proton nuclear magnetic resonance spectroscopy in an effort to differentiate individuals with psychiatric disorders, including schizophrenia and bipolar disorder.
Sleep abnormalities are common in schizophrenia, often even before psychosis onset, but the mechanisms behind this are unclear; therefore, researchers analyzed a possible link between genetic risk for schizophrenia and sleep phenotypes.
