Despite being common and often comorbid neurodevelopmental disorders, the study found robust yet subtle differences across age groups and the disorders in terms of cortical and subcortical brain structures.
Adverse events, including voluntary psychiatric admission, suicide attempt, serious violent incident, voluntary admission to a general medical ward, overdose of medication or painkillers, were highest among the combined group compared to the monotherapies.
A third of patients presented with an altered mental state, including 9 patients with unspecified encephalopathy, 7 with encephalitis, and 23 fulfilling the clinical definition for psychiatric diagnoses.
The researchers concluded that risk for MCI was associated with neurodegeneration and neuropsychiatric symptoms among adults aged 50 years and older, and that an abnormal FDG-PET was a stronger driving force for cognitive decline.
The researchers concluded that fluoxetine with or without CBT may be the best acute therapy for adolescents with moderate to severe depression, although patients, caregivers, and clinicians should carefully monitor any active intervention.
The researchers concluded that the correlation between interregional cortical thinning during maturation and expression patterns of genes associated with multiple psychiatric disorders suggested a common molecular process.
