While the most common recent approach in Alzheimer disease drug discovery is to directly target the β-amyloid pathway, the high prevalence of apolipoprotein E ε4 in Alzheimer disease and the ease of identifying ε4 carriers make the APOE genotype and its corresponding protein an appealing therapeutic target to slow Aβ accumulation.
Young people in trajectories reflecting more frequent nicotine vaping had a high probability of membership in a cannabis-use trajectory.
Psychometric studies suggest that hostility consists of multiple separate factors, but consensus is lacking. In this study the hierarchical structure of hostility is examined.
To identify markers of resistance to developing Parkinson disease among LRRK2 mutation carriers, metabolomic profiling in individuals with Parkinson disease and unaffected controls, were carried out with and without the LRRK2 mutation.
Researchers analyzed autopsy brain tissue from confirmed obstructive sleep apnea cases for amyloid beta and tau, hallmark proteins of Alzheimer disease.
Criticism perceived in an individual’s own environment may influence the response to criticism from a third-party perspective.
Examining the potential shared genetic liability of sleep deficits and cannabis use behaviors using multiple genomic methods.
One of the first studies to follow a large, population-based, cohort sample of children into adolescence in order to evaluate the natural history of insomnia symptoms and a broad number of relevant clinically and objectively assessed risk factors.
While the COVID-19 pandemic is a stress-inducing event, published empirical studies about mental health consequences are rare.
Does a relationship exist between the age of presentation to gender-affirming medical care and mental health difficulties?
