Dinko Kranjac, PhD, Medical Editor

Greater age-related decreases in volume of the putamen were observed in participants diagnosed with major depressive disorder compared with those of healthy controls.

Autism is a heritable neurodevelopmental disorder that is approximately 4 times more prevalent in males than
females.

Study provides further evidence for the effects of cognitive enhancement intervention on brain functional connectivity and cognitive performance in patients with schizophrenia.

Individuals suffering from depression, as well as persons diagnosed with temporal lobe epilepsy, present with dysfunction across several cognitive domains.

Cigarette smoking prevalence among persons with severe mental illness is approximately 3 times greater than the rate observed in the general population.

Approximately 2.5% of people worldwide are estimated to have bipolar spectrum disorders, which are a significant cause of neuropsychiatric disability.

The extent or severity of physical ailments and functional impairment needs to be carefully examined in order to successfully prevent suicide in late life.

Researchers studied social cognition and social problem solving in patients with schizophrenia by employing a validated test designed to assess emotion recognition abilities.

Study provides further evidence for the effects of white matter fiber abnormalities and neuroinflammation on positive symptoms in patients with schizophrenia.

Pupillary reactivity to emotional stimuli has been investigated to provide objective information about the risk for recurrence of depressive symptoms in women.

Lower diversity of microbial populations in the human gut has been identified in individuals with major depressive disorder.

New findings provide an insight about the association between white matter microstructure and the severity of schizophrenia clinical symptoms.

More than 75% of individuals with a current opioid addiction diagnosis, as well as 28% of control participants, presented with an addiction risk score over 52.

Researchers focused on single nucleotide polymorphisms associated with brain reward systems.

Researchers used voxel-based morphometry, which allows examination on a voxel-wise basis across the whole brain, to assess whether structural abnormalities in schizophrenia are static or progressive.

TSPO expression is frequently used as a biomarker for brain inflammation during PET imaging.

mBDNF/proBDNF ratio could potentially serve as a novel biomarker for mood disorders.

It is hypothesized that multiple single nucleotide polymorphisms (SNPs) work together to influence risk of complex neuropsychiatric disorders such as depression.

The immune system dysregulation may lead to or exacerbate neuropsychiatric conditions such as bipolar disorder.

Researchers used the auditory mismatch negativity (MMN) paradigm to evaluate its potential as a neurophysiological biomarker for psychosis.

Investigators examined the white matter tracts in patients diagnosed with the schizophrenia with predominantly negative symptoms.

Researchers explored the role of the dysregulated cannabinoid receptor system in patients diagnosed with schizophrenia.

Genetic variation can increase the predisposition to major depressive disorder.

Atrophy of numerous structures within the central nervous system has been observed in persons suffering from depression.

Compared with men, women diagnosed with AUD have higher rates of premature death due to alcohol abuse.

Basic Research Findings for the Practicing Clinician

In order clarify the abuse potential of modafinil, investigators characterized its psychostimulant profile by using mice.

The primary outcome in this study was reliability of patient-ratings on subjective well-being.

Opioid-related disorders are an emerging public health concern globally and in the United States.

This is the first meta-analysis to examine subjective emotion experience in psychopathy.

Investigators examined functional connectivity between the amygdala and the mPFC, bilateral temporal lobe, striatum, thalamus, cingulate cortex, and cerebellum in children diagnosed with autism and age-matched control participants.