APA 2018

Electroconvulsive Therapy Effective in Children With Autism

Electroconvulsive Therapy Effective in Children With Autism

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Electroconvulsive therapy (ECT) has been used for refractory psychiatric conditions in the United States since 1938. Despite this, few practitioners are comfortable recommending ECT for minors.

Smartphone-Based Monitoring for Bipolar Depression, Mania Symptoms: Results From MONARCA II Trial

Smartphone-Based Monitoring for Bipolar Depression, Mania Symptoms: Results From MONARCA II Trial

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The primary outcomes assessed were the differences in clinically assessed depressive and manic symptoms, as well as the rate of depressive and manic episodes.

Brexpiprazole Effective for Long-term Adjunctive Treatment of Major Depressive Disorder

Brexpiprazole Effective for Long-term Adjunctive Treatment of Major Depressive Disorder

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Treatment with brexpiprazole as adjunctive antidepressant therapy was safe and effective in patients with major depressive disorder.

Preliminary Virtual Reality Therapy Trial for Agoraphobia Shows Promise

Preliminary Virtual Reality Therapy Trial for Agoraphobia Shows Promise

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The development of effective implementation could make virtual reality a serious, accessible therapy for individuals with specific phobias and other anxiety disorders.

Depression in Patients With Dementia May Increase Risk for Heart Disease

Depression in Patients With Dementia May Increase Risk for Heart Disease

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Clinicians should take depression into careful consideration when treating patients with Alzheimer dementia, as the two conditions combined may predispose patients to cardiovascular disease more than either condition alone.

Positive Results Announced for Esketamine in Treatment-Resistant Depression

Positive Results Announced for Esketamine in Treatment-Resistant Depression

In both studies, the primary efficacy endpoint was change from baseline to Day 28 in Montgomery-Åsberg Depression Rating Scale (MADRS) total score.

Novel Buprenorphine Combination Therapy Shows Efficacy for MDD in Long-Term Trial

Novel Buprenorphine Combination Therapy Shows Efficacy for MDD in Long-Term Trial

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The average MADRS-10 scores decreased from baseline, and this decrease was maintained at the end of the study.

Deutetrabenazine Associated With Long-Term Improvements for Tardive Dyskinesia

Deutetrabenazine Associated With Long-Term Improvements for Tardive Dyskinesia

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Investigators examined the long-term efficacy of deutetrabenazine measured by Abnormal Involuntary Movement Scale, Clinical Global Impressions Scale, and Patients' Global Impression of Change Scale in real-word clinical practice settings.

Intranasal Esketamine Effective for Geriatric Patients With Treatment-Resistant Depression

Intranasal Esketamine Effective for Geriatric Patients With Treatment-Resistant Depression

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Intranasal esketamine in combination with oral antidepressants demonstrated significant reduction of depressive symptoms and improved overall severity of depressive illness and health-related quality of life and functioning.

Lurasidone May Be Effective for Long-Term Treatment of Pediatric Bipolar Depression

Lurasidone May Be Effective for Long-Term Treatment of Pediatric Bipolar Depression

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In pediatric patients with bipolar I depression, long-term treatment with lurasidone 20 mg/day is effective in reducing depressive symptoms.

Lofexidine Effective for Opioid Withdrawal Symptoms

Lofexidine Effective for Opioid Withdrawal Symptoms

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Investigators pooled data from 2 phase 3 placebo-controlled studies to evaluate the safety and efficacy of lofexidine for opioid withdrawal symptoms.

Adjunctive Raloxifene vs Antipsychotics Alone for Schizophrenia, Schizoaffective Disorder

Adjunctive Raloxifene vs Antipsychotics Alone for Schizophrenia, Schizoaffective Disorder

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Adjunctive raloxifene may reduce negative symptom scores in women with schizophrenia or schizoaffective disorder.

Antipsychotic Efficacy, Safety of ALKS 3831 Evaluated for Acute Schizophrenia

Antipsychotic Efficacy, Safety of ALKS 3831 Evaluated for Acute Schizophrenia

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The phase 3 study assessed the antipsychotic efficacy and safety of ALKS 3831 in patients with acute exacerbations of schizophrenia.

Dasotraline Treatment Effective for ADHD-Related Symptoms and Behaviors in Children

Dasotraline Treatment Effective for ADHD-Related Symptoms and Behaviors in Children

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In pediatric patients with ADHD, treatment with dasotraline 4 mg/day was effective in treating a range of ADHD-related symptoms and behaviors.

Antipsychotics Increase Risk for Metabolic Syndrome, CVD in Younger Patients

Antipsychotics Increase Risk for Metabolic Syndrome, CVD in Younger Patients

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Younger patients treated with antipsychotics after experiencing a first episode of psychosis are at an increased risk for metabolic syndrome and cardiovascular disease.

Efficacy of Bupropion, Escitalopram for Internet Gaming Disorder in MDD

Efficacy of Bupropion, Escitalopram for Internet Gaming Disorder in MDD

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Bupropion had a greater effect on reducing impulsivity and attention symptoms than escitalopram.

Major Depressive Disorder Linked With Poorer Hospital Outcomes in Parkinson Disease

Major Depressive Disorder Linked With Poorer Hospital Outcomes in Parkinson Disease

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Investigators analyzed the differences in hospitalization outcomes, comorbidities, and utilization of procedures in patients with PD vs patients with PD and MDD.

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