High-Fat Diet May Lead to Depression, Anxiety
the Psychiatry Advisor take:
Being overweight and having high blood sugar may contribute to anxiety and depression symptoms, and may even lead to changes in the brain, based on a study in mice.
Bruno Guiard, PhD, of the Research Centre on Animal Cognition at the University of Toulouse, France, and colleagues fed mice a high-fat diet to examine what metabolic and behavioral abnormalities it would bring on. Prior research has shown that the link between type 2 diabetes and depression is bidirectional.
The researchers also examined whether giving the mice the selective serotonin reuptake inhibitor antidepressant escitalopram could reduce any of the metabolic or behavioral impacts of the high-fat diet.
Increased body weight, hyperglycemia, and impaired glucose tolerance in following a high-fat diet was associated with anxiety and depression symptoms in the mice, the researchers reported in the British Journal of Pharmacology. But when the mice were taken off the high-fat diet, their anxiety symptoms waned.
In addition, the high-fat diet appeared to blunt any of the beneficial effects of the escitalopram.
“If we consider metabolic disorders as a putative treatment resistance predictor, this should encourage psychiatrists to put in place a personalized treatment with antidepressant drugs that do not further destabilize metabolism,” Guiard said in a statement.
When mice were taken off of a high-fat diet, however, anxiety symptoms declined.
A new study in mice reveals that increased body weight and high blood sugar as a result of consuming a high-fat diet may cause anxiety and depressive symptoms and measurable changes in the brain.
Also, the beneficial effects of an antidepressant were blunted in mice fed a high-fat diet. On the other hand, taking mice off a high-fat diet completely reversed the animals' metabolic impairments and lessened their anxious symptoms.
The results set the tone for future investigations on potential mechanisms that may link metabolic and psychiatric disorders.
Psychiatry Advisor Articles
- Adjunctive Therapies for Bipolar Disorder Show Promise, Need More Evidence
- Improving Performance of Everyday Activities Is Critical in Schizophrenia
- Analysis Finds Lithium Maintenance Most Effective as Monotherapy in Bipolar Disorder
- Web-Based Intervention Targets Parental Behaviors That May Affect Adolescent Anxiety, Depression
- Abnormalities of Cortical Thickness in Bipolar Disorder With Auditory Hallucinations
- The Way to the Head May Be Through the Gut: Probiotics for Depression
- Suicide-Screening Toolkit Can Help Identify Youths at High Risk for Suicide
- Agoraphobia: An Evolving Understanding of Definitions and Treatment
- Parental Pressure to Diet Linked With Long-term Harm in Adolescents
- Does Access to Medical Cannabis Reduce Risk for Opioid Abuse?
- Antidepressants Increase Seizure Risk in Youth and Severely Depressed
- Examining Associations Between Diabetes and Effects on Cognition
- Untreated Depression Common in Women of Childbearing Age
- Incidence of Psychiatric Disorders in Rheumatoid Arthritis
- Effect of Antidepressant Class, Dose on Pediatric Anxiety Disorders