Alzheimer Disease

Physical Frailty Associated With Symptoms of Dementia, Caregiver Burden in Alzheimer Disease

Physical Frailty Associated With Symptoms of Dementia, Caregiver Burden in Alzheimer Disease

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Per study data published in the Journal of Clinical Psychiatry, investigators hypothesized that the correlation between higher Frailty Index scores and increased caregiver burden was partially mediated by increased behavioral and psychological symptoms of dementia.

Cortisol Levels May Contribute to Global Cognitive Decline in Elderly Adults With Depression

Cortisol Levels May Contribute to Global Cognitive Decline in Elderly Adults With Depression

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These data indicate that cortisol levels may contribute to the cognitive decline observed in elderly adults with late-life depression.

Increased Levels of Human Herpesvirus Identified in Alzheimer Disease

Increased Levels of Human Herpesvirus Identified in Alzheimer Disease

Participants with Alzheimer disease have increased levels of 2 strains of human herpesvirus.

Sugary Drinks, Other Added Sugars May Up Risk for Alzheimer Disease

Sugary Drinks, Other Added Sugars May Up Risk for Alzheimer Disease

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Drinking sugary beverages has been previously linked to markers of preclinical Alzheimer disease, but the risk associated with consuming added sugars is not established.

Intensive Blood Pressure Control Cuts Combined Mild Cognitive Impairment, Dementia Risk

Intensive Blood Pressure Control Cuts Combined Mild Cognitive Impairment, Dementia Risk

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In the previous SPRINT study, researchers compared an intensive BP reduction strategy (target systolic BP <120 mmHg) vs standard BP reduction strategy (target systolic BP <140 mmHg).

Cannabinoid Shows Promise for Reducing Agitation, Aggression in Alzheimer Disease

Cannabinoid Shows Promise for Reducing Agitation, Aggression in Alzheimer Disease

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Although treatment with nabilone significantly improved agitation, cognition, and nutrition, the authors cautioned that sedation should be closely monitored.

Details of Montreal Cognitive Assessment Widely Publicized After President Donald Trump's Evaluation

Details of Montreal Cognitive Assessment Widely Publicized After President Donald Trump's Evaluation

Many published news articles included details of the Montreal Cognitive Assessment (MoCA) in association with President Trump, some of which invited readers to self-administer the test.

Association Between Alcohol Consumption, Cognitive Function Revealed

Association Between Alcohol Consumption, Cognitive Function Revealed

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Participants were drawn from the Health and Retirement Study, which provided multiple observations, genetic information, and previous alcohol use.

Some Statins May Be Associated With Cognition, Memory Deficits

Some Statins May Be Associated With Cognition, Memory Deficits

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Given the lack of differences seen via the NIS, the authors suggested that subjective questionnaires may not be a trustworthy method to assess possible statin-associated cognitive deficits.

Diclofenac Use Slows Cognitive Decline in Alzheimer Disease

Diclofenac Use Slows Cognitive Decline in Alzheimer Disease

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Results showed that most common NSAIDs, including aspirin, ibuprofen, naproxen, and celecoxib, did not alter cognitive degeneration in patients with mild cognitive impairment or Alzheimer disease.

Effect of ACE Inhibitors on Cognition in Alzheimer Disease Dementia

Effect of ACE Inhibitors on Cognition in Alzheimer Disease Dementia

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The genetically-mediated effects of angiotensin-converting enzyme (ACE) inhibitors showed an improvement in cognition in patients with Alzheimer disease dementia but not in functionality.

Aducanumab Beneficial in Cognitive, Functional Scores for Alzheimer Disease

Aducanumab Beneficial in Cognitive, Functional Scores for Alzheimer Disease

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The analysis suggests a beneficial effect of aducanumab on functional and cognitive domain scores in adults with Alzheimer disease.

Memantine Plus Cholinesterase Inhibitors Improves Psychosis, Neurobehavioral Symptoms in Alzheimer Disease

Memantine Plus Cholinesterase Inhibitors Improves Psychosis, Neurobehavioral Symptoms in Alzheimer Disease

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Investigators pooled data from patients from 3 phase 3, 24-week, randomized, placebo-controlled trials of MEM in patients with Alzheimer disease receiving concurrent ChEIs.

Cognitive Impairment Profiles Differ Between Parkinson Disease and Alzheimer Disease

Cognitive Impairment Profiles Differ Between Parkinson Disease and Alzheimer Disease

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As the neurodegenerative processes of Alzheimer disease and Parkinson disease are different, early cognitive impairment also present differently in these diseases.

Benzodiazepines, Related Drugs Associated With Modestly Increased Risk for Alzheimer Disease

Benzodiazepines, Related Drugs Associated With Modestly Increased Risk for Alzheimer Disease

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Given the frequent use of benzodiazepines among older people, even a small increase in absolute risk may be a serious matter on a population level.

Mortality in Alzheimer Disease Not Strongly Associated With Antipsychotics

Mortality in Alzheimer Disease Not Strongly Associated With Antipsychotics

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These results suggest that antipsychotic exposure has no impact on relative mortality.

Phonemic Verbal Advantage in Mild Cognitive Impairment May Predict Risk for Alzheimer Disease

Phonemic Verbal Advantage in Mild Cognitive Impairment May Predict Risk for Alzheimer Disease

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Patients with a phonemic advantage at baseline should be followed more closely with a higher index of suspicion for progression to Alzheimer disease.

Safety, Efficacy of Deep Brain Stimulation for Alzheimer Disease Examined

Safety, Efficacy of Deep Brain Stimulation for Alzheimer Disease Examined

The use of deep brain stimulation at the VC/VS region is well tolerated for patients with Alzheimer disease.

Alzheimer Disease and Associated Comorbidities: Investigating Modifiable Risk Factors

Alzheimer Disease and Associated Comorbidities: Investigating Modifiable Risk Factors

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Obesity and associated comorbidities are seen to be potential contributers to Alzheimer disease pathophysiology.

Alzheimer Disease Progression in Patients With MCI Predicted by EEG, Language Deficits

Alzheimer Disease Progression in Patients With MCI Predicted by EEG, Language Deficits

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Language deficits as well as EEG recordings may be of value for predicting Alzheimer's disease in patients with mild cognitive impairment.

Abnormal MRI and CSF Findings May Predict Risk for Alzheimer Disease

Abnormal MRI and CSF Findings May Predict Risk for Alzheimer Disease

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In patients with mild cognitive impairment, CSF and MRI findings are highly predicitve of Alzheimer disease and dementia risk.

Antidepressant Use and Dementia Risk in the Elderly

Antidepressant Use and Dementia Risk in the Elderly

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Antidepressants categorized as potentially inappropriate medication for elderly patients were associated with an increased risk of dementia.

Dementia Not Associated With Use of Proton-pump Inhibitors

Dementia Not Associated With Use of Proton-pump Inhibitors

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Risk for dementia is not increased by the use of PPIs.

Alzheimer's Disease Skill Loss Reversed With Memory Coaching, Support

Alzheimer's Disease Skill Loss Reversed With Memory Coaching, Support

With special training and medication, Alzheimer's patients can relearn some basic skills.

Crossword Puzzles Benefit Cognitive Performance, Memory

Crossword Puzzles Benefit Cognitive Performance, Memory

Performance was consistently better in those who reported engaging in puzzles, and generally improved incrementally with the frequency of puzzle use.

Sleep Quality May Impact Alzheimer's Disease Pathology

Sleep Quality May Impact Alzheimer's Disease Pathology

More research is needed to assess the effect of modifying sleep on the brain.

Dementia May Not Be Benefited By Weight Loss Interventions

Dementia May Not Be Benefited By Weight Loss Interventions

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Dementia may not be preventable by weight loss interventions focused on increased physical activity and portion control.

Greater Dementia Probability For Adults With Persistent Pain

Greater Dementia Probability For Adults With Persistent Pain

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Older adults with constant pain showed an increase in rapid memory loss and greater probability of dementia than older adults without constant pain.

Alzheimer's Disease Not Linked to Low Body Mass Index

Alzheimer's Disease Not Linked to Low Body Mass Index

Individuals with Alzheimer's disease are more likely to have low BMIs due to loss of appetite and weight loss in the early stages of the disease.

Many Patients With Alzheimer's Discontinue AChEIs

Many Patients With Alzheimer's Discontinue AChEIs

More than 81% of participants reported adverse events, but rates were similar between groups.

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