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ZAROXOLYN
Edema
Hypertension
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Drug Name:

ZAROXOLYN Rx

Generic Name and Formulations:
Metolazone 2.5mg, 5mg, 10mg; tabs.

Company:
UCB Inc.

Therapeutic Use:

Indications for ZAROXOLYN:

Edema.

Adult:

5–20mg once daily.

Children:

Not recommended.

Contraindications:

Do not interchange brands. Anuria. Hepatic coma or precoma. Sulfonamide allergy.

Warnings/Precautions:

For switching with Mykrox see literature. Renal or hepatic dysfunction. Azotemia. Arrhythmias. Diabetes. Gout. SLE. Monitor fluids, electrolytes, BUN. K+ supplements or K+-sparing diuretics may be needed. Discontinue if electrolyte disorders develop rapidly. Pregnancy (Cat.B). Nursing mothers: not recommended.

Interactions:

Digitalis, lithium toxicity. Furosemide, other diuretics increase fluid loss. Antagonizes antidiabetic, antigout medications, methenamine. Monitor anticoagulants. May potentiate nondepolarizing muscle relaxants, tubocurarine. ACTH, corticosteroids increase hypokalemia risk. Antagonized by NSAIDs, salicylates. Orthostatic hypotension, enhanced antihypertensive effects with alcohol, CNS depressants, other antihypertensives.

Pharmacological Class:

Quinazoline.

Adverse Reactions:

Electrolyte/metabolic disturbances (esp. hypokalemia), syncope, hyperglycemia, hyperuricemia, hypercalcemia, orthostatic hypotension, photosensitivity, GI disturbances, blood dyscrasias, chest or joint pain, cutaneous vasculitis.

How Supplied:

Tabs—100, 1000

Indications for ZAROXOLYN:

Hypertension.

Adult:

2.5–5mg once daily.

Children:

Not recommended.

Contraindications:

Do not interchange brands. Anuria. Hepatic coma or precoma. Sulfonamide allergy.

Warnings/Precautions:

For switching with Mykrox see literature. Renal or hepatic dysfunction. Azotemia. Arrhythmias. Diabetes. Gout. SLE. Monitor fluids, electrolytes, BUN. K+ supplements or K+-sparing diuretics may be needed. Discontinue if electrolyte disorders develop rapidly. Pregnancy (Cat.B). Nursing mothers: not recommended.

Interactions:

Digitalis, lithium toxicity. Furosemide, other diuretics increase fluid loss. Antagonizes antidiabetic, antigout medications, methenamine. Monitor anticoagulants. May potentiate nondepolarizing muscle relaxants, tubocurarine. ACTH, corticosteroids increase hypokalemia risk. Antagonized by NSAIDs, salicylates. Orthostatic hypotension, enhanced antihypertensive effects with alcohol, CNS depressants, other antihypertensives.

Pharmacological Class:

Diuretic (quinazoline).

Adverse Reactions:

Electrolyte/metabolic disturbances (esp. hypokalemia), syncope, hyperglycemia, hyperuricemia, hypercalcemia, orthostatic hypotension, photosensitivity, GI disturbances, blood dyscrasias, chest or joint pain, cutaneous vasculitis.

How Supplied:

Tabs—100, 1000

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